Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade

Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades, targeting M1 macrophage polarization has been suggested as a promising therapeutic strategy for autoimmune arthritis. P300/CBP-associated factor (PCAF) is a h...

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Detalles Bibliográficos
Autores principales: Li, Jinteng, Ye, Feng, Xu, Xiaojun, Xu, Peitao, Wang, Peng, Zheng, Guan, Ye, Guiwen, Yu, Wenhui, Su, Zepeng, Lin, Jiajie, Che, Yunshu, Liu, Zhidong, Feng, Pei, Cao, Qian, Li, Dateng, Xie, Zhongyu, Wu, Yanfeng, Shen, Huiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439630/
https://www.ncbi.nlm.nih.gov/pubmed/37598147
http://dx.doi.org/10.1186/s12951-023-02012-z

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