Cargando…

Renal Colic Pain Management by Tamsulosin with Morphine Versus Morphine in Adults: A Randomized Clinical Trial

BACKGROUND: Acute renal colic is one of the most painful situations in patients’ life. The best management modality for pain alleviation is of paramount importance. OBJECTIVES: This study aimed to evaluate the effect of intravenously administered morphine and oral tamsulosin compared to the independ...

Descripción completa

Detalles Bibliográficos
Autores principales: Talebi Doluee, Morteza, Shams, Aida, Keshvari Shirvan, Maliheh, DadgarMoghadam, Maliheh, Sadrzadeh, Sayyed Majid, VafadarMoradi, Elnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brieflands 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439690/
https://www.ncbi.nlm.nih.gov/pubmed/37601962
http://dx.doi.org/10.5812/aapm-134627
_version_ 1785093006072741888
author Talebi Doluee, Morteza
Shams, Aida
Keshvari Shirvan, Maliheh
DadgarMoghadam, Maliheh
Sadrzadeh, Sayyed Majid
VafadarMoradi, Elnaz
author_facet Talebi Doluee, Morteza
Shams, Aida
Keshvari Shirvan, Maliheh
DadgarMoghadam, Maliheh
Sadrzadeh, Sayyed Majid
VafadarMoradi, Elnaz
author_sort Talebi Doluee, Morteza
collection PubMed
description BACKGROUND: Acute renal colic is one of the most painful situations in patients’ life. The best management modality for pain alleviation is of paramount importance. OBJECTIVES: This study aimed to evaluate the effect of intravenously administered morphine and oral tamsulosin compared to the independent use of morphine in patients with renal colic. METHODS: This double-blind clinical trial was conducted on 200 patients aged 18 to 55 years with renal colic referred to the tertiary level referral hospital. The patients were randomly assigned to two groups, A and B. The subjects in group A were treated with intravenously administered morphine and oral tamsulosin hydrochloride capsules, while group B received morphine and control. The patients’ pain intensity was evaluated using a visual analog scale. RESULTS: The mean age of the patients was 35.34 ± 8.32, and 72% were males. Before the study, the mean pain intensity was higher in the tamsulosin group (8.67 ± 1.53) than in the control group (7.85 ± 2.05; P = 0.003). After four and six hours, the mean pain intensity was significantly lower in the tamsulosin group (P = 0.028 and P = 0.008, respectively). According to the results, the pain intensity was significantly reduced six hours after the treatment compared to the pre-therapy phase (P < 0.001). CONCLUSIONS: Given the significant effect of tamsulosin on pain alleviation in patients with renal colic, this medicine can be used as a complementary treatment to manage the pain in these patients and reduce the administration of narcotics.
format Online
Article
Text
id pubmed-10439690
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Brieflands
record_format MEDLINE/PubMed
spelling pubmed-104396902023-08-20 Renal Colic Pain Management by Tamsulosin with Morphine Versus Morphine in Adults: A Randomized Clinical Trial Talebi Doluee, Morteza Shams, Aida Keshvari Shirvan, Maliheh DadgarMoghadam, Maliheh Sadrzadeh, Sayyed Majid VafadarMoradi, Elnaz Anesth Pain Med Research Article BACKGROUND: Acute renal colic is one of the most painful situations in patients’ life. The best management modality for pain alleviation is of paramount importance. OBJECTIVES: This study aimed to evaluate the effect of intravenously administered morphine and oral tamsulosin compared to the independent use of morphine in patients with renal colic. METHODS: This double-blind clinical trial was conducted on 200 patients aged 18 to 55 years with renal colic referred to the tertiary level referral hospital. The patients were randomly assigned to two groups, A and B. The subjects in group A were treated with intravenously administered morphine and oral tamsulosin hydrochloride capsules, while group B received morphine and control. The patients’ pain intensity was evaluated using a visual analog scale. RESULTS: The mean age of the patients was 35.34 ± 8.32, and 72% were males. Before the study, the mean pain intensity was higher in the tamsulosin group (8.67 ± 1.53) than in the control group (7.85 ± 2.05; P = 0.003). After four and six hours, the mean pain intensity was significantly lower in the tamsulosin group (P = 0.028 and P = 0.008, respectively). According to the results, the pain intensity was significantly reduced six hours after the treatment compared to the pre-therapy phase (P < 0.001). CONCLUSIONS: Given the significant effect of tamsulosin on pain alleviation in patients with renal colic, this medicine can be used as a complementary treatment to manage the pain in these patients and reduce the administration of narcotics. Brieflands 2023-04-10 /pmc/articles/PMC10439690/ /pubmed/37601962 http://dx.doi.org/10.5812/aapm-134627 Text en Copyright © 2023, Author(s) https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Talebi Doluee, Morteza
Shams, Aida
Keshvari Shirvan, Maliheh
DadgarMoghadam, Maliheh
Sadrzadeh, Sayyed Majid
VafadarMoradi, Elnaz
Renal Colic Pain Management by Tamsulosin with Morphine Versus Morphine in Adults: A Randomized Clinical Trial
title Renal Colic Pain Management by Tamsulosin with Morphine Versus Morphine in Adults: A Randomized Clinical Trial
title_full Renal Colic Pain Management by Tamsulosin with Morphine Versus Morphine in Adults: A Randomized Clinical Trial
title_fullStr Renal Colic Pain Management by Tamsulosin with Morphine Versus Morphine in Adults: A Randomized Clinical Trial
title_full_unstemmed Renal Colic Pain Management by Tamsulosin with Morphine Versus Morphine in Adults: A Randomized Clinical Trial
title_short Renal Colic Pain Management by Tamsulosin with Morphine Versus Morphine in Adults: A Randomized Clinical Trial
title_sort renal colic pain management by tamsulosin with morphine versus morphine in adults: a randomized clinical trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439690/
https://www.ncbi.nlm.nih.gov/pubmed/37601962
http://dx.doi.org/10.5812/aapm-134627
work_keys_str_mv AT talebidolueemorteza renalcolicpainmanagementbytamsulosinwithmorphineversusmorphineinadultsarandomizedclinicaltrial
AT shamsaida renalcolicpainmanagementbytamsulosinwithmorphineversusmorphineinadultsarandomizedclinicaltrial
AT keshvarishirvanmaliheh renalcolicpainmanagementbytamsulosinwithmorphineversusmorphineinadultsarandomizedclinicaltrial
AT dadgarmoghadammaliheh renalcolicpainmanagementbytamsulosinwithmorphineversusmorphineinadultsarandomizedclinicaltrial
AT sadrzadehsayyedmajid renalcolicpainmanagementbytamsulosinwithmorphineversusmorphineinadultsarandomizedclinicaltrial
AT vafadarmoradielnaz renalcolicpainmanagementbytamsulosinwithmorphineversusmorphineinadultsarandomizedclinicaltrial