Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction

AIMS: Heart failure is a condition with high mortality rates, and there is a lack of therapies that directly target maladaptive changes in the extracellular matrix (ECM), such as fibrosis. We investigated whether the ECM enzyme known as A disintegrin and metalloprotease with thrombospondin motif (AD...

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Detalles Bibliográficos
Autores principales: Vistnes, Maria, Erusappan, Pugazendhi Murugan, Sasi, Athiramol, Nordén, Einar Sjaastad, Bergo, Kaja Knudsen, Romaine, Andreas, Lunde, Ida Gjervold, Zhang, Lili, Olsen, Maria Belland, Øgaard, Jonas, Carlson, Cathrine Rein, Wang, Christian Hjorth, Riise, Jon, Dahl, Christen Peder, Fiane, Arnt Eltvedt, Hauge-Iversen, Ida Marie, Espe, Emil, Melleby, Arne Olav, Tønnessen, Theis, Aronsen, Jan Magnus, Sjaastad, Ivar, Christensen, Geir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439713/
https://www.ncbi.nlm.nih.gov/pubmed/37216909
http://dx.doi.org/10.1093/cvr/cvad078

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