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Successful Treatment of Bilateral Renal Mucormycosis With Isavuconazole: A Case Report
Isolated renal mucormycosis (IRM) is a rare disease with high mortality, more commonly seen in immunocompromised patients. Management has traditionally included antifungal drugs with or without nephrectomy. We present the case of a 34-year-old female with a past medical history of type 1 diabetes me...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439839/ https://www.ncbi.nlm.nih.gov/pubmed/37605691 http://dx.doi.org/10.7759/cureus.42219 |
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author | Najjar, Yaseen Botros, Shirley Acker, Emily Ramani, Ananthakrishnan Beers, Kelly |
author_facet | Najjar, Yaseen Botros, Shirley Acker, Emily Ramani, Ananthakrishnan Beers, Kelly |
author_sort | Najjar, Yaseen |
collection | PubMed |
description | Isolated renal mucormycosis (IRM) is a rare disease with high mortality, more commonly seen in immunocompromised patients. Management has traditionally included antifungal drugs with or without nephrectomy. We present the case of a 34-year-old female with a past medical history of type 1 diabetes mellitus and intravenous heroin use who presented with fever, flank pain, hematuria, and vomiting. She was found to have an oliguric acute kidney injury (AKI) with a serum creatinine (Cr) of 2.5 mg/dL. CT showed bilateral emphysematous pyelonephritis and ureteral cultures grew Rhizopus species. Amphotericin B was started before being switched to isavuconazole due to worsening AKI, and hemodialysis was only required transiently. Rather than the traditional approach to treatment, a conservative approach that preserved kidney function was utilized, and the patient was successfully treated with six months of isavuconazole. |
format | Online Article Text |
id | pubmed-10439839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-104398392023-08-21 Successful Treatment of Bilateral Renal Mucormycosis With Isavuconazole: A Case Report Najjar, Yaseen Botros, Shirley Acker, Emily Ramani, Ananthakrishnan Beers, Kelly Cureus Urology Isolated renal mucormycosis (IRM) is a rare disease with high mortality, more commonly seen in immunocompromised patients. Management has traditionally included antifungal drugs with or without nephrectomy. We present the case of a 34-year-old female with a past medical history of type 1 diabetes mellitus and intravenous heroin use who presented with fever, flank pain, hematuria, and vomiting. She was found to have an oliguric acute kidney injury (AKI) with a serum creatinine (Cr) of 2.5 mg/dL. CT showed bilateral emphysematous pyelonephritis and ureteral cultures grew Rhizopus species. Amphotericin B was started before being switched to isavuconazole due to worsening AKI, and hemodialysis was only required transiently. Rather than the traditional approach to treatment, a conservative approach that preserved kidney function was utilized, and the patient was successfully treated with six months of isavuconazole. Cureus 2023-07-20 /pmc/articles/PMC10439839/ /pubmed/37605691 http://dx.doi.org/10.7759/cureus.42219 Text en Copyright © 2023, Najjar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Urology Najjar, Yaseen Botros, Shirley Acker, Emily Ramani, Ananthakrishnan Beers, Kelly Successful Treatment of Bilateral Renal Mucormycosis With Isavuconazole: A Case Report |
title | Successful Treatment of Bilateral Renal Mucormycosis With Isavuconazole: A Case Report |
title_full | Successful Treatment of Bilateral Renal Mucormycosis With Isavuconazole: A Case Report |
title_fullStr | Successful Treatment of Bilateral Renal Mucormycosis With Isavuconazole: A Case Report |
title_full_unstemmed | Successful Treatment of Bilateral Renal Mucormycosis With Isavuconazole: A Case Report |
title_short | Successful Treatment of Bilateral Renal Mucormycosis With Isavuconazole: A Case Report |
title_sort | successful treatment of bilateral renal mucormycosis with isavuconazole: a case report |
topic | Urology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439839/ https://www.ncbi.nlm.nih.gov/pubmed/37605691 http://dx.doi.org/10.7759/cureus.42219 |
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