The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model

The constitutive photomorphogenesis 9 (COP9) signalosome (CSN) is a deNEDDylase controlling ubiquitination activity of cullin-RING-E3 ligases (CRLs) and thus the levels of key cellular proteins. While the CSN and its catalytic subunit CSN5 have been extensively studied in cancer, its role in inflamm...

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Detalles Bibliográficos
Autores principales: Tian, Yuan, Milic, Jelena, Monasor, Laura Sebastián, Chakraborty, Rahul, Wang, Sijia, Yuan, Yue, Asare, Yaw, Behrends, Christian, Tahirovic, Sabina, Bernhagen, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439869/
https://www.ncbi.nlm.nih.gov/pubmed/37597109
http://dx.doi.org/10.1007/s00018-023-04911-8

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