Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the IGF2 precursor, pro-IGF2(156), leads to the formation of two IGF2 proforms, big-IGF2(87) and big-IGF2(104). Unprocessed and mainly no...

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Detalles Bibliográficos
Autores principales: Potalitsyn, Pavlo, Mrázková, Lucie, Selicharová, Irena, Tencerová, Michaela, Ferenčáková, Michaela, Chrudinová, Martina, Turnovská, Tereza, Brzozowski, Andrzej Marek, Marek, Aleš, Kaminský, Jakub, Jiráček, Jiří, Žáková, Lenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439913/
https://www.ncbi.nlm.nih.gov/pubmed/37598269
http://dx.doi.org/10.1038/s42003-023-05239-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439913/
https://www.ncbi.nlm.nih.gov/pubmed/37598269
http://dx.doi.org/10.1038/s42003-023-05239-6

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