Cargando…

Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the IGF2 precursor, pro-IGF2(156), leads to the formation of two IGF2 proforms, big-IGF2(87) and big-IGF2(104). Unprocessed and mainly no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Potalitsyn, Pavlo, Mrázková, Lucie, Selicharová, Irena, Tencerová, Michaela, Ferenčáková, Michaela, Chrudinová, Martina, Turnovská, Tereza, Brzozowski, Andrzej Marek, Marek, Aleš, Kaminský, Jakub, Jiráček, Jiří, Žáková, Lenka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439913/ https://www.ncbi.nlm.nih.gov/pubmed/37598269 http://dx.doi.org/10.1038/s42003-023-05239-6

Ejemplares similares

A radioligand binding assay for the insulin-like growth factor 2 receptor
por: Potalitsyn, Pavlo, et al.
Publicado: (2020)

The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn(2+) levels
por: Dzianová, Petra, et al.
Publicado: (2020)

Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation
por: Kertisová, Anna, et al.
Publicado: (2023)

Defective IGF-1 prohormone N-glycosylation and reduced IGF-1 receptor signaling activation in congenital disorders of glycosylation
por: Di Patria, Laura, et al.
Publicado: (2022)

A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding
por: Chrudinová, Martina, et al.
Publicado: (2018)

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses
por: Macháčková, Kateřina, et al.
Publicado: (2019)

Characterization of insulin crystalline form in isolated β-cell secretory granules
por: Asai, Seiya, et al.
Publicado: (2022)

The intrinsically disordered E-domains regulate the IGF-1 prohormones stability, subcellular localisation and secretion
por: Annibalini, Giosuè, et al.
Publicado: (2018)

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex
por: Žáková, Lenka, et al.
Publicado: (2014)

Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young
por: Křížková, Květoslava, et al.
Publicado: (2014)

From venom peptides to a potential diabetes treatment
por: Jiráček, Jiří, et al.
Publicado: (2019)

Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs
por: Jiráček, Jiří, et al.
Publicado: (2017)

Insight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human Insulin
por: Kosinová, Lucie, et al.
Publicado: (2014)

Human bone marrow stromal cells: the impact of anticoagulants on stem cell properties
por: Ferencakova, Michaela, et al.
Publicado: (2023)

Rational steering of insulin binding specificity by intra-chain chemical crosslinking
por: Viková, Jitka, et al.
Publicado: (2016)

rhIGF-1 Therapy for Growth Failure and IGF-1 Deficiency in Congenital Disorder of Glycosylation Ia (PMM2 Deficiency)
por: Miller, Bradley S., et al.
Publicado: (2013)

Recombinant Insulin-Like Growth Factor 1 Dimers: Receptor Binding Affinities and Activation Abilities
por: Lin, Jingjing, et al.
Publicado: (2023)

Cross-Linking/Mass Spectrometry Uncovers Details of Insulin-Like Growth Factor Interaction With Insect Insulin Binding Protein Imp-L2
por: Pompach, Petr, et al.
Publicado: (2019)

Glycosylation Analysis of Urinary Peptidome Highlights IGF2 Glycopeptides in Association with CKD
por: Lohia, Sonnal, et al.
Publicado: (2023)

Characterization of viral insulins reveals white adipose tissue-specific effects in mice
por: Chrudinová, Martina, et al.
Publicado: (2020)

Characterization of Viral Insulin-Like Peptides Reveals Unique White Adipose Tissue Specific Characteristics
por: Chrudinova, Martina, et al.
Publicado: (2021)

A Python Analytical Pipeline to Identify Prohormone Precursors and Predict Prohormone Cleavage Sites
por: Southey, Bruce R., et al.
Publicado: (2008)

IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes
Publicado: (1993)

Microscopy examination of red blood and yeast cell agglutination induced by bacterial lectins
por: Mrázková, Jana, et al.
Publicado: (2019)

Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls
por: Chang, Hua-Pin, et al.
Publicado: (2018)

Expression of mutant ELH prohormones in AtT-20 cells: the relationship between prohormone processing and sorting
Publicado: (1993)

IGF-I, IGF-II, and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I Receptor
por: Versteyhe, Soetkin, et al.
Publicado: (2013)

Noncoding RNA actions through IGFs and IGF binding proteins in cancer
por: Kerr, Aidan, et al.
Publicado: (2022)

Insulin receptor compensates for IGF1R inhibition and directly induces mitogenic activity in prostate cancer cells
por: Weinstein, Doron, et al.
Publicado: (2014)

Changes in the proteomes of the hemocytes and fat bodies of the flesh fly Sarcophaga bullata larvae after infection by Escherichia coli
por: Masova, Alice, et al.
Publicado: (2010)

Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?
por: Ameline, Baptiste, et al.
Publicado: (2020)

Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans
por: Viola, Cristina M., et al.
Publicado: (2023)

New Modulators for IGF-I Activity within IGF-I Processing Products
por: Brisson, Becky K., et al.
Publicado: (2013)

Interaction between IGF-IR and ER Induced by E2 and IGF-I
por: Yu, Zhenghong, et al.
Publicado: (2013)

Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions
por: Zhong, Yingbin, et al.
Publicado: (2017)

Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer
por: Sipos, Ferenc, et al.
Publicado: (2017)

IGF2 and IGF1R mRNAs Are Detectable in Human Spermatozoa
por: Cannarella, Rossella, et al.
Publicado: (2020)

Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip
por: DEMİREL, Esra, et al.
Publicado: (2023)

Sperm-carried IGF2 downregulated the expression of mitogens produced by Sertoli cells: A paracrine mechanism for regulating spermatogenesis?
por: Cannarella, Rossella, et al.
Publicado: (2022)

Prohormones in the Early Diagnosis of Cardiac Syncope
por: Badertscher, Patrick, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_b01ni9j8kd5o272asipd6kd8a2