CD98hc is a target for brain delivery of biotherapeutics

Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3A2) of heterodimeric amino acid transporters (TV(CD98hc))....

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Detalles Bibliográficos
Autores principales: Chew, Kylie S., Wells, Robert C., Moshkforoush, Arash, Chan, Darren, Lechtenberg, Kendra J., Tran, Hai L., Chow, Johann, Kim, Do Jin, Robles-Colmenares, Yaneth, Srivastava, Devendra B., Tong, Raymond K., Tong, Mabel, Xa, Kaitlin, Yang, Alexander, Zhou, Yinhan, Akkapeddi, Padma, Annamalai, Lakshman, Bajc, Kaja, Blanchette, Marie, Cherf, Gerald Maxwell, Earr, Timothy K., Gill, Audrey, Huynh, David, Joy, David, Knight, Kristen N., Lac, Diana, Leung, Amy Wing-Sze, Lexa, Katrina W., Liau, Nicholas P. D., Becerra, Isabel, Malfavon, Mario, McInnes, Joseph, Nguyen, Hoang N., Lozano, Edwin I., Pizzo, Michelle E., Roche, Elysia, Sacayon, Patricia, Calvert, Meredith E. K., Daneman, Richard, Dennis, Mark S., Duque, Joseph, Gadkar, Kapil, Lewcock, Joseph W., Mahon, Cathal S., Meisner, René, Solanoy, Hilda, Thorne, Robert G., Watts, Ryan J., Zuchero, Y. Joy Yu, Kariolis, Mihalis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439950/
https://www.ncbi.nlm.nih.gov/pubmed/37598178
http://dx.doi.org/10.1038/s41467-023-40681-4

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