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Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin and Body Mass Index Predicts In Vitro Fertilization Oocyte Maturation Rate: A Cross-Sectional Study
BACKGROUND: In vitro fertilization (IVF) remains a main treatment for infertility cases. Post-injection human chorionic gonadotropin (hCG) level is an essential factor in determining oocyte maturation rate in IVF. This study aimed to determine the relationship between 12 hours post-injection serum h...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Royan Institute
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439995/ https://www.ncbi.nlm.nih.gov/pubmed/37577910 http://dx.doi.org/10.22074/IJFS.2023.555467.1315 |
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author | Wiweko, Budi Surya, Ervan Silvana, Vita Maidarti, Mila Kemal Harzif, Achmad Pratama, Gita Sumapraja, Kanadi Muharam, R Hestiantoro, Andon |
author_facet | Wiweko, Budi Surya, Ervan Silvana, Vita Maidarti, Mila Kemal Harzif, Achmad Pratama, Gita Sumapraja, Kanadi Muharam, R Hestiantoro, Andon |
author_sort | Wiweko, Budi |
collection | PubMed |
description | BACKGROUND: In vitro fertilization (IVF) remains a main treatment for infertility cases. Post-injection human chorionic gonadotropin (hCG) level is an essential factor in determining oocyte maturation rate in IVF. This study aimed to determine the relationship between 12 hours post-injection serum hCG level and oocyte maturation rate among IVF participants. MATERIALS AND METHODS: A cross-sectional study on IVF participants was done at a tertiary hospital in Indonesia from January 2020 to December 2021. Subjects were injected with 250 μg of recombinant-hCG (r-hCG) subcutaneously. Twelve hours post-injection serum hCG levels and oocyte maturation rate data were retrieved and analyzed accordingly. RESULTS: Twenty-eight subjects were recruited into the study. Higher 12 hours post-injection serum hCG was related to oocyte maturation rate (P=0.046). The cut-off point of 12 hours post-injection serum hCG to predict better oocyte maturation rate was 90.15 mIU/mL (sensitivity 68.2%, specificity 83.3%). Oocyte maturation rate may be predicted using body mass index (BMI) and 12 hours post-injection serum hCG. CONCLUSION: Higher 12 hours post-injection serum hCG was associated with a higher oocyte maturation rate in IVF subjects. |
format | Online Article Text |
id | pubmed-10439995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-104399952023-10-01 Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin and Body Mass Index Predicts In Vitro Fertilization Oocyte Maturation Rate: A Cross-Sectional Study Wiweko, Budi Surya, Ervan Silvana, Vita Maidarti, Mila Kemal Harzif, Achmad Pratama, Gita Sumapraja, Kanadi Muharam, R Hestiantoro, Andon Int J Fertil Steril Research Article BACKGROUND: In vitro fertilization (IVF) remains a main treatment for infertility cases. Post-injection human chorionic gonadotropin (hCG) level is an essential factor in determining oocyte maturation rate in IVF. This study aimed to determine the relationship between 12 hours post-injection serum hCG level and oocyte maturation rate among IVF participants. MATERIALS AND METHODS: A cross-sectional study on IVF participants was done at a tertiary hospital in Indonesia from January 2020 to December 2021. Subjects were injected with 250 μg of recombinant-hCG (r-hCG) subcutaneously. Twelve hours post-injection serum hCG levels and oocyte maturation rate data were retrieved and analyzed accordingly. RESULTS: Twenty-eight subjects were recruited into the study. Higher 12 hours post-injection serum hCG was related to oocyte maturation rate (P=0.046). The cut-off point of 12 hours post-injection serum hCG to predict better oocyte maturation rate was 90.15 mIU/mL (sensitivity 68.2%, specificity 83.3%). Oocyte maturation rate may be predicted using body mass index (BMI) and 12 hours post-injection serum hCG. CONCLUSION: Higher 12 hours post-injection serum hCG was associated with a higher oocyte maturation rate in IVF subjects. Royan Institute 2023 2023-08-07 /pmc/articles/PMC10439995/ /pubmed/37577910 http://dx.doi.org/10.22074/IJFS.2023.555467.1315 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited. https://creativecommons.org/licenses/by-nc/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial 3.0 (CC BY-NC 3.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wiweko, Budi Surya, Ervan Silvana, Vita Maidarti, Mila Kemal Harzif, Achmad Pratama, Gita Sumapraja, Kanadi Muharam, R Hestiantoro, Andon Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin and Body Mass Index Predicts In Vitro Fertilization Oocyte Maturation Rate: A Cross-Sectional Study |
title | Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin
and Body Mass Index Predicts In Vitro Fertilization Oocyte
Maturation Rate: A Cross-Sectional Study |
title_full | Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin
and Body Mass Index Predicts In Vitro Fertilization Oocyte
Maturation Rate: A Cross-Sectional Study |
title_fullStr | Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin
and Body Mass Index Predicts In Vitro Fertilization Oocyte
Maturation Rate: A Cross-Sectional Study |
title_full_unstemmed | Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin
and Body Mass Index Predicts In Vitro Fertilization Oocyte
Maturation Rate: A Cross-Sectional Study |
title_short | Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin
and Body Mass Index Predicts In Vitro Fertilization Oocyte
Maturation Rate: A Cross-Sectional Study |
title_sort | twelve hours post-injection serum human chorionic gonadotropin
and body mass index predicts in vitro fertilization oocyte
maturation rate: a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439995/ https://www.ncbi.nlm.nih.gov/pubmed/37577910 http://dx.doi.org/10.22074/IJFS.2023.555467.1315 |
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