The Equipoise Between the Treatment of Glioblastoma and the Risk of Secondary Acute Myelogenous Leukemia: An Illustrative Case Report

We present a case report of a 56-year-old woman who was diagnosed with biopsy-proven left thalamic glioblastoma multiforme (GBM). She was treated with standard concurrent chemotherapy and radiation, as well as a 2-year period of adjuvant temozolomide. She relapsed 2 ½ years after starting her initia...

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Autores principales: Harari-Turquie, Moises, Moturi, Krishna Rekha, Horton, Darrell D., Rabinowitz, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440052/
https://www.ncbi.nlm.nih.gov/pubmed/37596951
http://dx.doi.org/10.1177/23247096231193266
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author Harari-Turquie, Moises
Moturi, Krishna Rekha
Horton, Darrell D.
Rabinowitz, Ian
author_facet Harari-Turquie, Moises
Moturi, Krishna Rekha
Horton, Darrell D.
Rabinowitz, Ian
author_sort Harari-Turquie, Moises
collection PubMed
description We present a case report of a 56-year-old woman who was diagnosed with biopsy-proven left thalamic glioblastoma multiforme (GBM). She was treated with standard concurrent chemotherapy and radiation, as well as a 2-year period of adjuvant temozolomide. She relapsed 2 ½ years after starting her initial therapy and was treated with bevacizumab and lomustine, but she relapsed. She was then placed on a phase 1/2 clinical trial that included KHK2455 and mogamulizumab-kpkc individually and in combination for almost 4 years. She had a rapid demise due to the development of a neutropenic pneumonia and treatment-induced acute myeloid leukemia (AML) and elected for hospice care.
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spelling pubmed-104400522023-08-21 The Equipoise Between the Treatment of Glioblastoma and the Risk of Secondary Acute Myelogenous Leukemia: An Illustrative Case Report Harari-Turquie, Moises Moturi, Krishna Rekha Horton, Darrell D. Rabinowitz, Ian J Investig Med High Impact Case Rep Case Report We present a case report of a 56-year-old woman who was diagnosed with biopsy-proven left thalamic glioblastoma multiforme (GBM). She was treated with standard concurrent chemotherapy and radiation, as well as a 2-year period of adjuvant temozolomide. She relapsed 2 ½ years after starting her initial therapy and was treated with bevacizumab and lomustine, but she relapsed. She was then placed on a phase 1/2 clinical trial that included KHK2455 and mogamulizumab-kpkc individually and in combination for almost 4 years. She had a rapid demise due to the development of a neutropenic pneumonia and treatment-induced acute myeloid leukemia (AML) and elected for hospice care. SAGE Publications 2023-08-19 /pmc/articles/PMC10440052/ /pubmed/37596951 http://dx.doi.org/10.1177/23247096231193266 Text en © 2023 American Federation for Medical Research https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Harari-Turquie, Moises
Moturi, Krishna Rekha
Horton, Darrell D.
Rabinowitz, Ian
The Equipoise Between the Treatment of Glioblastoma and the Risk of Secondary Acute Myelogenous Leukemia: An Illustrative Case Report
title The Equipoise Between the Treatment of Glioblastoma and the Risk of Secondary Acute Myelogenous Leukemia: An Illustrative Case Report
title_full The Equipoise Between the Treatment of Glioblastoma and the Risk of Secondary Acute Myelogenous Leukemia: An Illustrative Case Report
title_fullStr The Equipoise Between the Treatment of Glioblastoma and the Risk of Secondary Acute Myelogenous Leukemia: An Illustrative Case Report
title_full_unstemmed The Equipoise Between the Treatment of Glioblastoma and the Risk of Secondary Acute Myelogenous Leukemia: An Illustrative Case Report
title_short The Equipoise Between the Treatment of Glioblastoma and the Risk of Secondary Acute Myelogenous Leukemia: An Illustrative Case Report
title_sort equipoise between the treatment of glioblastoma and the risk of secondary acute myelogenous leukemia: an illustrative case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440052/
https://www.ncbi.nlm.nih.gov/pubmed/37596951
http://dx.doi.org/10.1177/23247096231193266
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