The A328 V/E (rs2887147) polymorphisms in human tryptophan hydroxylase 2 compromise enzyme activity

Human tryptophan hydroxylase 2 (hTPH2) is the rate-limiting enzyme for serotonin biosynthesis in the brain. A number of naturally-occurring single nucleotide polymorphisms (SNPs) have been reported for hTPH2. We investigated the activity and kinetic characteristics of the most common missense polymo...

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Detalles Bibliográficos
Autores principales: Carkaci-Salli, Nurgul, Bewley, Maria C., Tekin, Izel, Flanagan, John M., Vrana, Kent E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440358/
https://www.ncbi.nlm.nih.gov/pubmed/37608910
http://dx.doi.org/10.1016/j.bbrep.2023.101527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440358/
https://www.ncbi.nlm.nih.gov/pubmed/37608910
http://dx.doi.org/10.1016/j.bbrep.2023.101527

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