Cargando…
Case report: A case of sepsis caused by rickettsial infection-induced hemophagocytic syndrome
Hemophagocytic lymphohistiocytosis (HLH) is a rare histiocytic disorder characterized by reactive hyperplasia of the mononuclear phagocytic system, which is primarily caused by dysfunction of cytotoxic killer cells and natural killer cells, leading to antigen clearance barriers and the overactivatio...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440429/ https://www.ncbi.nlm.nih.gov/pubmed/37608831 http://dx.doi.org/10.3389/fmed.2023.1209174 |
_version_ | 1785093149177151488 |
---|---|
author | Cao, Yanli Liu, Peijun Song, Qiuling Wang, Jing |
author_facet | Cao, Yanli Liu, Peijun Song, Qiuling Wang, Jing |
author_sort | Cao, Yanli |
collection | PubMed |
description | Hemophagocytic lymphohistiocytosis (HLH) is a rare histiocytic disorder characterized by reactive hyperplasia of the mononuclear phagocytic system, which is primarily caused by dysfunction of cytotoxic killer cells and natural killer cells, leading to antigen clearance barriers and the overactivation of the mononuclear phagocytic system due to continuous antigen stimulation. HLH encompasses a group of clinical syndromes marked by the overproduction of inflammatory cytokines. A 68-year-old Chinese man presented with persistent fever, chills, nausea, and vomiting; the patient had no history of any underlying conditions. Laboratory investigations revealed decreased levels of red blood cells, white blood cells, and platelets, along with reduced natural killer cell activity, increased CD25, hyperferritinemia, and the detection of Rickettsia DNA in his blood, meeting the diagnostic criteria of the Histiocyte Society HLH-2004 guidelines. The patient was treated with antibiotics, improving anemia, glucocorticoid therapy, and continuous renal replacement therapy (CRRT), temporarily improving his condition. However, the patient died after 2 years from chronic renal failure caused by septic shock. |
format | Online Article Text |
id | pubmed-10440429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104404292023-08-22 Case report: A case of sepsis caused by rickettsial infection-induced hemophagocytic syndrome Cao, Yanli Liu, Peijun Song, Qiuling Wang, Jing Front Med (Lausanne) Medicine Hemophagocytic lymphohistiocytosis (HLH) is a rare histiocytic disorder characterized by reactive hyperplasia of the mononuclear phagocytic system, which is primarily caused by dysfunction of cytotoxic killer cells and natural killer cells, leading to antigen clearance barriers and the overactivation of the mononuclear phagocytic system due to continuous antigen stimulation. HLH encompasses a group of clinical syndromes marked by the overproduction of inflammatory cytokines. A 68-year-old Chinese man presented with persistent fever, chills, nausea, and vomiting; the patient had no history of any underlying conditions. Laboratory investigations revealed decreased levels of red blood cells, white blood cells, and platelets, along with reduced natural killer cell activity, increased CD25, hyperferritinemia, and the detection of Rickettsia DNA in his blood, meeting the diagnostic criteria of the Histiocyte Society HLH-2004 guidelines. The patient was treated with antibiotics, improving anemia, glucocorticoid therapy, and continuous renal replacement therapy (CRRT), temporarily improving his condition. However, the patient died after 2 years from chronic renal failure caused by septic shock. Frontiers Media S.A. 2023-08-07 /pmc/articles/PMC10440429/ /pubmed/37608831 http://dx.doi.org/10.3389/fmed.2023.1209174 Text en Copyright © 2023 Cao, Liu, Song and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Cao, Yanli Liu, Peijun Song, Qiuling Wang, Jing Case report: A case of sepsis caused by rickettsial infection-induced hemophagocytic syndrome |
title | Case report: A case of sepsis caused by rickettsial infection-induced hemophagocytic syndrome |
title_full | Case report: A case of sepsis caused by rickettsial infection-induced hemophagocytic syndrome |
title_fullStr | Case report: A case of sepsis caused by rickettsial infection-induced hemophagocytic syndrome |
title_full_unstemmed | Case report: A case of sepsis caused by rickettsial infection-induced hemophagocytic syndrome |
title_short | Case report: A case of sepsis caused by rickettsial infection-induced hemophagocytic syndrome |
title_sort | case report: a case of sepsis caused by rickettsial infection-induced hemophagocytic syndrome |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440429/ https://www.ncbi.nlm.nih.gov/pubmed/37608831 http://dx.doi.org/10.3389/fmed.2023.1209174 |
work_keys_str_mv | AT caoyanli casereportacaseofsepsiscausedbyrickettsialinfectioninducedhemophagocyticsyndrome AT liupeijun casereportacaseofsepsiscausedbyrickettsialinfectioninducedhemophagocyticsyndrome AT songqiuling casereportacaseofsepsiscausedbyrickettsialinfectioninducedhemophagocyticsyndrome AT wangjing casereportacaseofsepsiscausedbyrickettsialinfectioninducedhemophagocyticsyndrome |