Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern

Despite similar infection rates, COVID-19 has resulted in more deaths in men than women. To understand the underlying mechanisms behind this sex-biased difference in disease severity, we infected K18-human angiotensin converting enzyme 2 (ACE2) mice of both sexes with SARS-CoV-2. Our study revealed...

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Detalles Bibliográficos
Autores principales: Onodera, Yu, Liang, Jady, Li, Yuchong, Griffin, Bryan, Thanabalasingam, Thenuka, Lu, Cong, Zhu, JiaYi, Liu, Mingyao, Moraes, Theo, Zheng, Wenhua, Khateeb, Jasmin, Khang, Julie, Huang, Yongbo, Jerkic, Mirjana, Nakane, Masaki, Baker, Andrew, Orser, Beverley, Chen, Ya-Wen, Wirnsberger, Gerald, Penninger, Josef M., Rotstein, Ori D., Slutsky, Arthur S., Li, Yimin, Mubareka, Samira, Zhang, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440513/
https://www.ncbi.nlm.nih.gov/pubmed/37609639
http://dx.doi.org/10.1016/j.isci.2023.107470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440513/
https://www.ncbi.nlm.nih.gov/pubmed/37609639
http://dx.doi.org/10.1016/j.isci.2023.107470

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