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Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images

Mechanical stress and strain conditions are closely related to atherosclerotic plaque progression and rupture and have been under intensive investigations in recent years. It is well known that arteries have a three-layer structure: intima, media and adventitia. However, in vivo image-based multilay...

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Autores principales: Huang, Mengde, Maehara, Akiko, Tang, Dalin, Zhu, Jian, Wang, Liang, Lv, Rui, Zhu, Yanwen, Zhang, Xiaoguo, Matsumura, Mitsuaki, Chen, Lijuan, Ma, Genshan, Mintz, Gary S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440539/
https://www.ncbi.nlm.nih.gov/pubmed/37608838
http://dx.doi.org/10.3389/fphys.2023.1251401
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author Huang, Mengde
Maehara, Akiko
Tang, Dalin
Zhu, Jian
Wang, Liang
Lv, Rui
Zhu, Yanwen
Zhang, Xiaoguo
Matsumura, Mitsuaki
Chen, Lijuan
Ma, Genshan
Mintz, Gary S.
author_facet Huang, Mengde
Maehara, Akiko
Tang, Dalin
Zhu, Jian
Wang, Liang
Lv, Rui
Zhu, Yanwen
Zhang, Xiaoguo
Matsumura, Mitsuaki
Chen, Lijuan
Ma, Genshan
Mintz, Gary S.
author_sort Huang, Mengde
collection PubMed
description Mechanical stress and strain conditions are closely related to atherosclerotic plaque progression and rupture and have been under intensive investigations in recent years. It is well known that arteries have a three-layer structure: intima, media and adventitia. However, in vivo image-based multilayer plaque models are not available in the current literature due to lack of multilayer image segmentation data. A multilayer segmentation and repairing technique was introduced to segment coronary plaque optical coherence tomography (OCT) image to obtain its three-layer vessel structure. A total of 200 OCT slices from 20 patients (13 male; 7 female) were used to construct multilayer and single-layer 3D thin-slice models to calculate plaque stress and strain and compare model differences. Our results indicated that the average maximum plaque stress values of 20 patients from multilayer and single-layer models were 385.13 ± 110.09 kPa and 270.91 ± 95.86 kPa, respectively. The relative difference was 42.2%, with single-layer stress serving as the base value. The average mean plaque stress values from multilayer and single-layer models were 129.59 ± 32.77 kPa and 93.27 ± 18.20 kPa, respectively, with a relative difference of 38.9%. The maximum and mean plaque strain values obtained from the multilayer models were 11.6% and 19.0% higher than those from the single-layer models. Similarly, the maximum and mean cap strains showed increases of 9.6% and 12.9% over those from the single-layer models. These findings suggest that use of multilayer models could improve plaque stress and strain calculation accuracy and may have large impact on plaque progression and vulnerability investigation and potential clinical applications. Further large-scale studies are needed to validate our findings.
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spelling pubmed-104405392023-08-22 Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images Huang, Mengde Maehara, Akiko Tang, Dalin Zhu, Jian Wang, Liang Lv, Rui Zhu, Yanwen Zhang, Xiaoguo Matsumura, Mitsuaki Chen, Lijuan Ma, Genshan Mintz, Gary S. Front Physiol Physiology Mechanical stress and strain conditions are closely related to atherosclerotic plaque progression and rupture and have been under intensive investigations in recent years. It is well known that arteries have a three-layer structure: intima, media and adventitia. However, in vivo image-based multilayer plaque models are not available in the current literature due to lack of multilayer image segmentation data. A multilayer segmentation and repairing technique was introduced to segment coronary plaque optical coherence tomography (OCT) image to obtain its three-layer vessel structure. A total of 200 OCT slices from 20 patients (13 male; 7 female) were used to construct multilayer and single-layer 3D thin-slice models to calculate plaque stress and strain and compare model differences. Our results indicated that the average maximum plaque stress values of 20 patients from multilayer and single-layer models were 385.13 ± 110.09 kPa and 270.91 ± 95.86 kPa, respectively. The relative difference was 42.2%, with single-layer stress serving as the base value. The average mean plaque stress values from multilayer and single-layer models were 129.59 ± 32.77 kPa and 93.27 ± 18.20 kPa, respectively, with a relative difference of 38.9%. The maximum and mean plaque strain values obtained from the multilayer models were 11.6% and 19.0% higher than those from the single-layer models. Similarly, the maximum and mean cap strains showed increases of 9.6% and 12.9% over those from the single-layer models. These findings suggest that use of multilayer models could improve plaque stress and strain calculation accuracy and may have large impact on plaque progression and vulnerability investigation and potential clinical applications. Further large-scale studies are needed to validate our findings. Frontiers Media S.A. 2023-08-07 /pmc/articles/PMC10440539/ /pubmed/37608838 http://dx.doi.org/10.3389/fphys.2023.1251401 Text en Copyright © 2023 Huang, Maehara, Tang, Zhu, Wang, Lv, Zhu, Zhang, Matsumura, Chen, Ma and Mintz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Huang, Mengde
Maehara, Akiko
Tang, Dalin
Zhu, Jian
Wang, Liang
Lv, Rui
Zhu, Yanwen
Zhang, Xiaoguo
Matsumura, Mitsuaki
Chen, Lijuan
Ma, Genshan
Mintz, Gary S.
Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images
title Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images
title_full Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images
title_fullStr Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images
title_full_unstemmed Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images
title_short Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images
title_sort comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440539/
https://www.ncbi.nlm.nih.gov/pubmed/37608838
http://dx.doi.org/10.3389/fphys.2023.1251401
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