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Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes

PURPOSE: To assess age-related biometric changes of the eye in nonhuman primates (NHPs), to and decipher the growth and aging rates and their comparability with humans. METHODS: Ocular anatomic measurements were performed on 341 macaca fascicularis aged 0.5 to 23 years via multimodal approaches incl...

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Autores principales: Xue, Ying, Cao, Yingxue, Fan, Shuxin, Xu, Mingming, Yang, Ziqi, Zhou, Lingli, Shi, Le, Ou, Lechun, Li, Yuying, Qing, Wenjie, Zou, Zhicheng, Mao, Fuxiang, Wang, Ningli, Duh, Elia J., Yi, Wei, Liu, Xialin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440610/
https://www.ncbi.nlm.nih.gov/pubmed/37589983
http://dx.doi.org/10.1167/iovs.64.11.23
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author Xue, Ying
Cao, Yingxue
Fan, Shuxin
Xu, Mingming
Yang, Ziqi
Zhou, Lingli
Shi, Le
Ou, Lechun
Li, Yuying
Qing, Wenjie
Zou, Zhicheng
Mao, Fuxiang
Wang, Ningli
Duh, Elia J.
Yi, Wei
Liu, Xialin
author_facet Xue, Ying
Cao, Yingxue
Fan, Shuxin
Xu, Mingming
Yang, Ziqi
Zhou, Lingli
Shi, Le
Ou, Lechun
Li, Yuying
Qing, Wenjie
Zou, Zhicheng
Mao, Fuxiang
Wang, Ningli
Duh, Elia J.
Yi, Wei
Liu, Xialin
author_sort Xue, Ying
collection PubMed
description PURPOSE: To assess age-related biometric changes of the eye in nonhuman primates (NHPs), to and decipher the growth and aging rates and their comparability with humans. METHODS: Ocular anatomic measurements were performed on 341 macaca fascicularis aged 0.5 to 23 years via multimodal approaches including IOLMaster 700. Linear or polynomial regression models were simulated to determine the best fitted age-related function. The metrics were compared with human equivalents in published reports. RESULTS: Macaques exhibited a postnatal eye growth pattern similar to humans, characterized by continuous eye extension coordinated with dramatic reshaping of the lens but not the cornea. The age-related growth of lens thickness (LT), anterior chamber depth (ACD), and axis length (AL) exhibited nonlinear and bipolar patterns. The inflection points were 10 to 12 years old for LT and ACD and 13 to 15 years old for AL in macaques, which were comparable in chronological age at a ratio of ∼1: ratio with that in humans. In contrast, the speed of aging, including the increase in lens density and the decrease in retinal nerve fiber layer thickness, was comparable in relative age at a ratio of ∼1:3 according to the differences in lifespan between macaques and humans. Lens density was a robust indicator for the aging process. CONCLUSIONS: Macaque eyes recapitulated the age-related process of human eyes to varying extents with different growth and aging rates. Chronological age or relative age should be considered in different scenarios when macaques are included in preclinical studies.
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spelling pubmed-104406102023-08-22 Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes Xue, Ying Cao, Yingxue Fan, Shuxin Xu, Mingming Yang, Ziqi Zhou, Lingli Shi, Le Ou, Lechun Li, Yuying Qing, Wenjie Zou, Zhicheng Mao, Fuxiang Wang, Ningli Duh, Elia J. Yi, Wei Liu, Xialin Invest Ophthalmol Vis Sci Anatomy and Pathology/Oncology PURPOSE: To assess age-related biometric changes of the eye in nonhuman primates (NHPs), to and decipher the growth and aging rates and their comparability with humans. METHODS: Ocular anatomic measurements were performed on 341 macaca fascicularis aged 0.5 to 23 years via multimodal approaches including IOLMaster 700. Linear or polynomial regression models were simulated to determine the best fitted age-related function. The metrics were compared with human equivalents in published reports. RESULTS: Macaques exhibited a postnatal eye growth pattern similar to humans, characterized by continuous eye extension coordinated with dramatic reshaping of the lens but not the cornea. The age-related growth of lens thickness (LT), anterior chamber depth (ACD), and axis length (AL) exhibited nonlinear and bipolar patterns. The inflection points were 10 to 12 years old for LT and ACD and 13 to 15 years old for AL in macaques, which were comparable in chronological age at a ratio of ∼1: ratio with that in humans. In contrast, the speed of aging, including the increase in lens density and the decrease in retinal nerve fiber layer thickness, was comparable in relative age at a ratio of ∼1:3 according to the differences in lifespan between macaques and humans. Lens density was a robust indicator for the aging process. CONCLUSIONS: Macaque eyes recapitulated the age-related process of human eyes to varying extents with different growth and aging rates. Chronological age or relative age should be considered in different scenarios when macaques are included in preclinical studies. The Association for Research in Vision and Ophthalmology 2023-08-17 /pmc/articles/PMC10440610/ /pubmed/37589983 http://dx.doi.org/10.1167/iovs.64.11.23 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Anatomy and Pathology/Oncology
Xue, Ying
Cao, Yingxue
Fan, Shuxin
Xu, Mingming
Yang, Ziqi
Zhou, Lingli
Shi, Le
Ou, Lechun
Li, Yuying
Qing, Wenjie
Zou, Zhicheng
Mao, Fuxiang
Wang, Ningli
Duh, Elia J.
Yi, Wei
Liu, Xialin
Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes
title Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes
title_full Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes
title_fullStr Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes
title_full_unstemmed Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes
title_short Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes
title_sort nonhuman primate eyes display variable growth and aging rates in alignment with human eyes
topic Anatomy and Pathology/Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440610/
https://www.ncbi.nlm.nih.gov/pubmed/37589983
http://dx.doi.org/10.1167/iovs.64.11.23
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