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Clinical characteristics of adults with self-reported diagnosed asthma and/or COPD: data from the BOLD Australia Study
BACKGROUND: Diagnosis of asthma and chronic obstructive pulmonary disease (COPD) in the community is variable, often without spirometry. Some studies report that adults with both diagnostic labels (asthma+COPD) have worse health outcomes than those with asthma or COPD only, but data for Australian a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440648/ https://www.ncbi.nlm.nih.gov/pubmed/37609600 http://dx.doi.org/10.1183/23120541.00098-2023 |
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author | Zhou, Yijun Ampon, Maria R. Abramson, Michael J. James, Alan L. Maguire, Graeme P. Wood-Baker, Richard Johns, David P. Marks, Guy B. Reddel, Helen K. Toelle, Brett G. |
author_facet | Zhou, Yijun Ampon, Maria R. Abramson, Michael J. James, Alan L. Maguire, Graeme P. Wood-Baker, Richard Johns, David P. Marks, Guy B. Reddel, Helen K. Toelle, Brett G. |
author_sort | Zhou, Yijun |
collection | PubMed |
description | BACKGROUND: Diagnosis of asthma and chronic obstructive pulmonary disease (COPD) in the community is variable, often without spirometry. Some studies report that adults with both diagnostic labels (asthma+COPD) have worse health outcomes than those with asthma or COPD only, but data for Australian adults are limited. We investigated the relationship between clinical characteristics and self-reported diagnoses of asthma, COPD and both. METHOD: We used data from the BOLD Australia study, which included randomly selected adults aged ≥40 years from six study sites. The BOLD questionnaires and spirometry test were used in all sites. Participants were grouped by self-reported diagnosis. Demographic and clinical characteristics and lung function were compared between groups. RESULTS: Of the study sample (n=3522), 336 reported asthma only, 172 reported COPD only, 77 reported asthma+COPD and 2937 reported neither. Fewer than half of participants with a COPD diagnosis (with or without asthma) had airflow limitation. Participants with asthma+COPD had more respiratory symptoms and greater airflow limitation than those with either diagnosis alone. Having asthma+COPD was independently associated with a higher probability of having clinically important breathlessness (modified Medical Research Council score ≥2) than asthma only (adjusted OR 3.44, 95% CI 1.86–6.33) or COPD only (adjusted OR 3.28, 95% CI 1.69–6.39). Airflow limitation (Global Initiative for Chronic Obstructive Lung Disease 2 or higher, using post-bronchodilator forced expiratory volume in 1 s/forced vital capacity ratio <0.7) was similar between asthma only and COPD only, but twice as prevalent in asthma+COPD (adjusted OR 2.18 and 2.58, respectively). CONCLUSIONS: Adults with diagnoses of asthma+COPD have a higher symptom and disease burden than those with diagnoses of asthma only or COPD only. These patients should receive regular comprehensive reviews because of the substantially increased burden of having both diagnoses. |
format | Online Article Text |
id | pubmed-10440648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-104406482023-08-22 Clinical characteristics of adults with self-reported diagnosed asthma and/or COPD: data from the BOLD Australia Study Zhou, Yijun Ampon, Maria R. Abramson, Michael J. James, Alan L. Maguire, Graeme P. Wood-Baker, Richard Johns, David P. Marks, Guy B. Reddel, Helen K. Toelle, Brett G. ERJ Open Res Original research articles BACKGROUND: Diagnosis of asthma and chronic obstructive pulmonary disease (COPD) in the community is variable, often without spirometry. Some studies report that adults with both diagnostic labels (asthma+COPD) have worse health outcomes than those with asthma or COPD only, but data for Australian adults are limited. We investigated the relationship between clinical characteristics and self-reported diagnoses of asthma, COPD and both. METHOD: We used data from the BOLD Australia study, which included randomly selected adults aged ≥40 years from six study sites. The BOLD questionnaires and spirometry test were used in all sites. Participants were grouped by self-reported diagnosis. Demographic and clinical characteristics and lung function were compared between groups. RESULTS: Of the study sample (n=3522), 336 reported asthma only, 172 reported COPD only, 77 reported asthma+COPD and 2937 reported neither. Fewer than half of participants with a COPD diagnosis (with or without asthma) had airflow limitation. Participants with asthma+COPD had more respiratory symptoms and greater airflow limitation than those with either diagnosis alone. Having asthma+COPD was independently associated with a higher probability of having clinically important breathlessness (modified Medical Research Council score ≥2) than asthma only (adjusted OR 3.44, 95% CI 1.86–6.33) or COPD only (adjusted OR 3.28, 95% CI 1.69–6.39). Airflow limitation (Global Initiative for Chronic Obstructive Lung Disease 2 or higher, using post-bronchodilator forced expiratory volume in 1 s/forced vital capacity ratio <0.7) was similar between asthma only and COPD only, but twice as prevalent in asthma+COPD (adjusted OR 2.18 and 2.58, respectively). CONCLUSIONS: Adults with diagnoses of asthma+COPD have a higher symptom and disease burden than those with diagnoses of asthma only or COPD only. These patients should receive regular comprehensive reviews because of the substantially increased burden of having both diagnoses. European Respiratory Society 2023-08-21 /pmc/articles/PMC10440648/ /pubmed/37609600 http://dx.doi.org/10.1183/23120541.00098-2023 Text en Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Original research articles Zhou, Yijun Ampon, Maria R. Abramson, Michael J. James, Alan L. Maguire, Graeme P. Wood-Baker, Richard Johns, David P. Marks, Guy B. Reddel, Helen K. Toelle, Brett G. Clinical characteristics of adults with self-reported diagnosed asthma and/or COPD: data from the BOLD Australia Study |
title | Clinical characteristics of adults with self-reported diagnosed asthma and/or COPD: data from the BOLD Australia Study |
title_full | Clinical characteristics of adults with self-reported diagnosed asthma and/or COPD: data from the BOLD Australia Study |
title_fullStr | Clinical characteristics of adults with self-reported diagnosed asthma and/or COPD: data from the BOLD Australia Study |
title_full_unstemmed | Clinical characteristics of adults with self-reported diagnosed asthma and/or COPD: data from the BOLD Australia Study |
title_short | Clinical characteristics of adults with self-reported diagnosed asthma and/or COPD: data from the BOLD Australia Study |
title_sort | clinical characteristics of adults with self-reported diagnosed asthma and/or copd: data from the bold australia study |
topic | Original research articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440648/ https://www.ncbi.nlm.nih.gov/pubmed/37609600 http://dx.doi.org/10.1183/23120541.00098-2023 |
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