Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse

In Alzheimer’s disease (AD), reactive astrocytes produce extracellular vesicles (EVs) that affect mitochondria in neurons. Here, we show that Aβ-induced generation of the sphingolipid ceramide by acid sphingomyelinase (A-SMase) triggered proinflammatory cytokine (C1q, TNF-α, IL-1α) release by microg...

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Detalles Bibliográficos
Autores principales: Crivelli, Simone M., Quadri, Zainuddin, Vekaria, Hemendra J., Zhu, Zhihui, Tripathi, Priyanka, Elsherbini, Ahmed, Zhang, Liping, Sullivan, Patrick G., Bieberich, Erhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440899/
https://www.ncbi.nlm.nih.gov/pubmed/37605262
http://dx.doi.org/10.1186/s40478-023-01633-7

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