Cargando…
Recent advances in metal nanoparticles to treat periodontitis
The gradual deterioration of the supporting periodontal tissues caused by periodontitis, a chronic multifactorial inflammatory disease, is thought to be triggered by the colonization of dysbiotic plaque biofilms in a vulnerable host. One of the most prevalent dental conditions in the world, periodon...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440939/ https://www.ncbi.nlm.nih.gov/pubmed/37605182 http://dx.doi.org/10.1186/s12951-023-02042-7 |
_version_ | 1785093262455865344 |
---|---|
author | Nasiri, Kamyar Masoumi, Seyed Mohammadreza Amini, Sara Goudarzi, Mina Tafreshi, Seyed Mobin Bagheri, Abbas Yasamineh, Saman alwan, Mariem Arellano, Meryelem Tania Churampi Gholizadeh, Omid |
author_facet | Nasiri, Kamyar Masoumi, Seyed Mohammadreza Amini, Sara Goudarzi, Mina Tafreshi, Seyed Mobin Bagheri, Abbas Yasamineh, Saman alwan, Mariem Arellano, Meryelem Tania Churampi Gholizadeh, Omid |
author_sort | Nasiri, Kamyar |
collection | PubMed |
description | The gradual deterioration of the supporting periodontal tissues caused by periodontitis, a chronic multifactorial inflammatory disease, is thought to be triggered by the colonization of dysbiotic plaque biofilms in a vulnerable host. One of the most prevalent dental conditions in the world, periodontitis is now the leading factor in adult tooth loss. When periodontitis does develop, it is treated by scraping the mineralized deposits and dental biofilm off the tooth surfaces. Numerous studies have shown that non-surgical treatment significantly improves clinical and microbiological indices in individuals with periodontitis. Although periodontal parameters have significantly improved, certain bacterial reservoirs often persist on root surfaces even after standard periodontal therapy. Periodontitis has been treated with local or systemic antibiotics as well as scaling and root planning. Since there aren't many brand-new antibiotics on the market, several researchers are currently concentrating on creating alternate methods of combating periodontal germs. There is a delay in a study on the subject of nanoparticle (NP) toxicity, which is especially concerned with mechanisms of action, while the area of nanomedicine develops. The most promising of them are metal NPs since they have potent antibacterial action. Metal NPs may be employed as efficient growth inhibitors in a variety of bacteria, making them useful for the treatment of periodontitis. In this way, the new metal NPs contributed significantly to the development of efficient anti-inflammatory and antibacterial platforms for the treatment of periodontitis. The current therapeutic effects of several metallic NPs on periodontitis are summarized in this study. This data might be used to develop NP-based therapeutic alternatives for the treatment of periodontal infections. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-10440939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104409392023-08-22 Recent advances in metal nanoparticles to treat periodontitis Nasiri, Kamyar Masoumi, Seyed Mohammadreza Amini, Sara Goudarzi, Mina Tafreshi, Seyed Mobin Bagheri, Abbas Yasamineh, Saman alwan, Mariem Arellano, Meryelem Tania Churampi Gholizadeh, Omid J Nanobiotechnology Review The gradual deterioration of the supporting periodontal tissues caused by periodontitis, a chronic multifactorial inflammatory disease, is thought to be triggered by the colonization of dysbiotic plaque biofilms in a vulnerable host. One of the most prevalent dental conditions in the world, periodontitis is now the leading factor in adult tooth loss. When periodontitis does develop, it is treated by scraping the mineralized deposits and dental biofilm off the tooth surfaces. Numerous studies have shown that non-surgical treatment significantly improves clinical and microbiological indices in individuals with periodontitis. Although periodontal parameters have significantly improved, certain bacterial reservoirs often persist on root surfaces even after standard periodontal therapy. Periodontitis has been treated with local or systemic antibiotics as well as scaling and root planning. Since there aren't many brand-new antibiotics on the market, several researchers are currently concentrating on creating alternate methods of combating periodontal germs. There is a delay in a study on the subject of nanoparticle (NP) toxicity, which is especially concerned with mechanisms of action, while the area of nanomedicine develops. The most promising of them are metal NPs since they have potent antibacterial action. Metal NPs may be employed as efficient growth inhibitors in a variety of bacteria, making them useful for the treatment of periodontitis. In this way, the new metal NPs contributed significantly to the development of efficient anti-inflammatory and antibacterial platforms for the treatment of periodontitis. The current therapeutic effects of several metallic NPs on periodontitis are summarized in this study. This data might be used to develop NP-based therapeutic alternatives for the treatment of periodontal infections. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2023-08-21 /pmc/articles/PMC10440939/ /pubmed/37605182 http://dx.doi.org/10.1186/s12951-023-02042-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Nasiri, Kamyar Masoumi, Seyed Mohammadreza Amini, Sara Goudarzi, Mina Tafreshi, Seyed Mobin Bagheri, Abbas Yasamineh, Saman alwan, Mariem Arellano, Meryelem Tania Churampi Gholizadeh, Omid Recent advances in metal nanoparticles to treat periodontitis |
title | Recent advances in metal nanoparticles to treat periodontitis |
title_full | Recent advances in metal nanoparticles to treat periodontitis |
title_fullStr | Recent advances in metal nanoparticles to treat periodontitis |
title_full_unstemmed | Recent advances in metal nanoparticles to treat periodontitis |
title_short | Recent advances in metal nanoparticles to treat periodontitis |
title_sort | recent advances in metal nanoparticles to treat periodontitis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440939/ https://www.ncbi.nlm.nih.gov/pubmed/37605182 http://dx.doi.org/10.1186/s12951-023-02042-7 |
work_keys_str_mv | AT nasirikamyar recentadvancesinmetalnanoparticlestotreatperiodontitis AT masoumiseyedmohammadreza recentadvancesinmetalnanoparticlestotreatperiodontitis AT aminisara recentadvancesinmetalnanoparticlestotreatperiodontitis AT goudarzimina recentadvancesinmetalnanoparticlestotreatperiodontitis AT tafreshiseyedmobin recentadvancesinmetalnanoparticlestotreatperiodontitis AT bagheriabbas recentadvancesinmetalnanoparticlestotreatperiodontitis AT yasaminehsaman recentadvancesinmetalnanoparticlestotreatperiodontitis AT alwanmariem recentadvancesinmetalnanoparticlestotreatperiodontitis AT arellanomeryelemtaniachurampi recentadvancesinmetalnanoparticlestotreatperiodontitis AT gholizadehomid recentadvancesinmetalnanoparticlestotreatperiodontitis |