Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension

Non-enzymatic activation of renin via its interaction with prorenin receptor (PRR) has been proposed as a key mechanism of local renin–angiotensin system (RAS) activation. The presence of renin and angiotensinogen has been reported in the rostral ventrolateral medulla (RVLM). Overactivation of bulbo...

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Detalles Bibliográficos
Autores principales: Mathieu, Natalia M, Fekete, Eva M, Muskus, Patricia C, Brozoski, Daniel T, Lu, Ko-Ting, Wackman, Kelsey K, Gomez, Javier, Fang, Shi, Reho, John J, Grobe, Connie C, Vazirabad, Ibrahim, Mouradian, Gary C, Hodges, Matthew R, Segar, Jeffrey L, Grobe, Justin L, Sigmund, Curt D, Nakagawa, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440998/
https://www.ncbi.nlm.nih.gov/pubmed/37609445
http://dx.doi.org/10.1093/function/zqad043

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