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Effects of Tai Chi combined with tDCS on cognitive function in patients with MCI: a randomized controlled trial

BACKGROUND: Mild cognitive impairment (MCI) is a critical stage of dementia. Previous reviews have suggested that physical exercise combined with non-invasive brain stimulation is more beneficial for improving cognitive function. However, no targeted studies have confirmed the effect of Tai Chi comb...

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Autores principales: Xu, Ying, Zhu, Jingfang, Liu, Hong, Qiu, Zhijie, Wu, Mengyuan, Liu, Jiao, Wu, Jingsong, Huang, Jia, Liu, Zhizhen, Liu, Weilin, Tao, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441111/
https://www.ncbi.nlm.nih.gov/pubmed/37608981
http://dx.doi.org/10.3389/fpubh.2023.1199246
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author Xu, Ying
Zhu, Jingfang
Liu, Hong
Qiu, Zhijie
Wu, Mengyuan
Liu, Jiao
Wu, Jingsong
Huang, Jia
Liu, Zhizhen
Liu, Weilin
Tao, Jing
author_facet Xu, Ying
Zhu, Jingfang
Liu, Hong
Qiu, Zhijie
Wu, Mengyuan
Liu, Jiao
Wu, Jingsong
Huang, Jia
Liu, Zhizhen
Liu, Weilin
Tao, Jing
author_sort Xu, Ying
collection PubMed
description BACKGROUND: Mild cognitive impairment (MCI) is a critical stage of dementia. Previous reviews have suggested that physical exercise combined with non-invasive brain stimulation is more beneficial for improving cognitive function. However, no targeted studies have confirmed the effect of Tai Chi combined with transcranial direct current stimulation (tDCS) on the improvement of cognitive function in patients with MCI. Thus, this randomized trial was conducted to assess the effect of Tai Chi combined with tDCS on the cognitive performance of patients with MCI. METHODS: From April 2018 to February 2020, a randomized, single-blind clinical trial was conducted, involving 180 participants with MCI who were divided into four intervention groups: Tai Chi combined with tDCS (TCT), Tai Chi combined with sham tDCS (TCS), walking combined with tDCS (WAT), and walking combined with sham tDCS (WAS). All participants were assessed at baseline and 12 weeks for global cognitive function, memory, attention, and executive function. RESULTS: At baseline, there were no significant differences in age, gender, education duration, body mass index, or the Baker Depression Inventory among the four groups (P ≥ 0.05). After 12 weeks of intervention, the TCT group showed greater improvements in MOCA scores, memory quotient scores, and digit-symbol coding task reaction time compared to the TCS, WAS, and WAT groups (P < 0.05). The TCT group also had a shorter Stroop test color reaction time compared to the WAS and WAT groups (P < 0.05), a higher increase in Auditory Verbal Learning Test-immediate recall than the TCS and WAT groups (P < 0.05), a shorter visual reaction time than the TCS group (P < 0.05), and a shorter sustained attention time compared to the WAT group (P < 0.05). CONCLUSION: Tai Chi combined with tDCS effectively improves global cognitive performance, memory, execution function, and attention in patients with MCI. These findings suggest the potential clinical use of Tai Chi combined with tDCS as a physical exercise combined with a non-invasive brain stimulation intervention to improve cognitive function in older adults with MCI. CLINICAL TRIAL REGISTRATION: ChiCTR1800015629.
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spelling pubmed-104411112023-08-22 Effects of Tai Chi combined with tDCS on cognitive function in patients with MCI: a randomized controlled trial Xu, Ying Zhu, Jingfang Liu, Hong Qiu, Zhijie Wu, Mengyuan Liu, Jiao Wu, Jingsong Huang, Jia Liu, Zhizhen Liu, Weilin Tao, Jing Front Public Health Public Health BACKGROUND: Mild cognitive impairment (MCI) is a critical stage of dementia. Previous reviews have suggested that physical exercise combined with non-invasive brain stimulation is more beneficial for improving cognitive function. However, no targeted studies have confirmed the effect of Tai Chi combined with transcranial direct current stimulation (tDCS) on the improvement of cognitive function in patients with MCI. Thus, this randomized trial was conducted to assess the effect of Tai Chi combined with tDCS on the cognitive performance of patients with MCI. METHODS: From April 2018 to February 2020, a randomized, single-blind clinical trial was conducted, involving 180 participants with MCI who were divided into four intervention groups: Tai Chi combined with tDCS (TCT), Tai Chi combined with sham tDCS (TCS), walking combined with tDCS (WAT), and walking combined with sham tDCS (WAS). All participants were assessed at baseline and 12 weeks for global cognitive function, memory, attention, and executive function. RESULTS: At baseline, there were no significant differences in age, gender, education duration, body mass index, or the Baker Depression Inventory among the four groups (P ≥ 0.05). After 12 weeks of intervention, the TCT group showed greater improvements in MOCA scores, memory quotient scores, and digit-symbol coding task reaction time compared to the TCS, WAS, and WAT groups (P < 0.05). The TCT group also had a shorter Stroop test color reaction time compared to the WAS and WAT groups (P < 0.05), a higher increase in Auditory Verbal Learning Test-immediate recall than the TCS and WAT groups (P < 0.05), a shorter visual reaction time than the TCS group (P < 0.05), and a shorter sustained attention time compared to the WAT group (P < 0.05). CONCLUSION: Tai Chi combined with tDCS effectively improves global cognitive performance, memory, execution function, and attention in patients with MCI. These findings suggest the potential clinical use of Tai Chi combined with tDCS as a physical exercise combined with a non-invasive brain stimulation intervention to improve cognitive function in older adults with MCI. CLINICAL TRIAL REGISTRATION: ChiCTR1800015629. Frontiers Media S.A. 2023-08-07 /pmc/articles/PMC10441111/ /pubmed/37608981 http://dx.doi.org/10.3389/fpubh.2023.1199246 Text en Copyright © 2023 Xu, Zhu, Liu, Qiu, Wu, Liu, Wu, Huang, Liu, Liu and Tao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Xu, Ying
Zhu, Jingfang
Liu, Hong
Qiu, Zhijie
Wu, Mengyuan
Liu, Jiao
Wu, Jingsong
Huang, Jia
Liu, Zhizhen
Liu, Weilin
Tao, Jing
Effects of Tai Chi combined with tDCS on cognitive function in patients with MCI: a randomized controlled trial
title Effects of Tai Chi combined with tDCS on cognitive function in patients with MCI: a randomized controlled trial
title_full Effects of Tai Chi combined with tDCS on cognitive function in patients with MCI: a randomized controlled trial
title_fullStr Effects of Tai Chi combined with tDCS on cognitive function in patients with MCI: a randomized controlled trial
title_full_unstemmed Effects of Tai Chi combined with tDCS on cognitive function in patients with MCI: a randomized controlled trial
title_short Effects of Tai Chi combined with tDCS on cognitive function in patients with MCI: a randomized controlled trial
title_sort effects of tai chi combined with tdcs on cognitive function in patients with mci: a randomized controlled trial
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441111/
https://www.ncbi.nlm.nih.gov/pubmed/37608981
http://dx.doi.org/10.3389/fpubh.2023.1199246
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