Mitigation of acetaminophen-induced liver toxicity by the novel phosphatidylinositol 3-kinase inhibitor alpelisib

The sterile inflammatory response mediated by Toll-like receptors (TLRs) 4 and 9 is implicated in the massive hepatic damage caused by acetaminophen (APAP)-overdose. There is a crosstalk between TLR-dependent signaling with other intracellular kinases like phosphatidylinositol 3-kinases (PI3Ks). Nev...

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Detalles Bibliográficos
Autores principales: Shaker, Mohamed E., Gomaa, Hesham A. M., Hazem, Sara H., Abdelgawad, Mohamed A., El-Mesery, Mohamed, Shaaban, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441125/
https://www.ncbi.nlm.nih.gov/pubmed/37608890
http://dx.doi.org/10.3389/fphar.2023.1212771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441125/
https://www.ncbi.nlm.nih.gov/pubmed/37608890
http://dx.doi.org/10.3389/fphar.2023.1212771

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