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Mitigation of acetaminophen-induced liver toxicity by the novel phosphatidylinositol 3-kinase inhibitor alpelisib

The sterile inflammatory response mediated by Toll-like receptors (TLRs) 4 and 9 is implicated in the massive hepatic damage caused by acetaminophen (APAP)-overdose. There is a crosstalk between TLR-dependent signaling with other intracellular kinases like phosphatidylinositol 3-kinases (PI3Ks). Nev...

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Detalles Bibliográficos
Autores principales:	Shaker, Mohamed E., Gomaa, Hesham A. M., Hazem, Sara H., Abdelgawad, Mohamed A., El-Mesery, Mohamed, Shaaban, Ahmed A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441125/ https://www.ncbi.nlm.nih.gov/pubmed/37608890 http://dx.doi.org/10.3389/fphar.2023.1212771

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