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Investigation of Serum Human Epididymitis Protein 4 Level in Rats with Experimental Acute Pancreatitis

BACKGROUND: We aimed to show whether the serum level of Human Epididymitis Protein 4 increases in rats with an experimental acute pancreatitis model created by cerulein. METHODS: This study included 24 male Sprague–Dawley rats which were randomly divided into 4 groups each containing 6 rats. Control...

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Autores principales: Acar, Ali, Ellidağ, Hamit Yaşar, Balaban, Kadir, Öcal, Serkan, Aslaner, Arif, Çakır, Tuğrul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Society of Gastroenterology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441141/
https://www.ncbi.nlm.nih.gov/pubmed/37078202
http://dx.doi.org/10.5152/tjg.2023.22489
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author Acar, Ali
Ellidağ, Hamit Yaşar
Balaban, Kadir
Öcal, Serkan
Aslaner, Arif
Çakır, Tuğrul
author_facet Acar, Ali
Ellidağ, Hamit Yaşar
Balaban, Kadir
Öcal, Serkan
Aslaner, Arif
Çakır, Tuğrul
author_sort Acar, Ali
collection PubMed
description BACKGROUND: We aimed to show whether the serum level of Human Epididymitis Protein 4 increases in rats with an experimental acute pancreatitis model created by cerulein. METHODS: This study included 24 male Sprague–Dawley rats which were randomly divided into 4 groups each containing 6 rats. Control: the group treated with saline, Group 1: pancreatitis group created with cerulein at a total dose of 80 µg/kg, Group 2: pancreatitis group created with cerulein at a total dose of 120 µg/kg, Group 3: pancreatitis group created with cerulein at a total dose of 160 µg/kg. RESULTS: There were statistically significant differences between edema, acinar necrosis, fat necrosis, and perivascular inflammation scores among the study groups. While the degree of all histopathological findings is lowest in the control group, pancreatic parenchyma damage increases as the amount of injected cerulein increases. There was no statistically significant difference between alanine aminotransferase, aspartate aminotransferase, and Human Epididymis Protein 4 values between study groups. On the other hand, there was a statistically significant difference between amylase and lipase values. The lipase value of the control group was significantly lower than the lipase value of the second and third groups. The amylase value of the control group was significantly lower than all other groups. The highest Human Epididymis Protein 4 value was measured as 104 pmol/L in the first pancreatitis group, where the severity of pancreatitis was mild. CONCLUSIONS: In the present study, it was concluded that the Human Epididymis Protein 4 value increased in the case of mild pancreatitis, but there is no correlation between the severity of pancreatitis and the Human Epididymis Protein 4 value.
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spelling pubmed-104411412023-08-22 Investigation of Serum Human Epididymitis Protein 4 Level in Rats with Experimental Acute Pancreatitis Acar, Ali Ellidağ, Hamit Yaşar Balaban, Kadir Öcal, Serkan Aslaner, Arif Çakır, Tuğrul Turk J Gastroenterol Original Article BACKGROUND: We aimed to show whether the serum level of Human Epididymitis Protein 4 increases in rats with an experimental acute pancreatitis model created by cerulein. METHODS: This study included 24 male Sprague–Dawley rats which were randomly divided into 4 groups each containing 6 rats. Control: the group treated with saline, Group 1: pancreatitis group created with cerulein at a total dose of 80 µg/kg, Group 2: pancreatitis group created with cerulein at a total dose of 120 µg/kg, Group 3: pancreatitis group created with cerulein at a total dose of 160 µg/kg. RESULTS: There were statistically significant differences between edema, acinar necrosis, fat necrosis, and perivascular inflammation scores among the study groups. While the degree of all histopathological findings is lowest in the control group, pancreatic parenchyma damage increases as the amount of injected cerulein increases. There was no statistically significant difference between alanine aminotransferase, aspartate aminotransferase, and Human Epididymis Protein 4 values between study groups. On the other hand, there was a statistically significant difference between amylase and lipase values. The lipase value of the control group was significantly lower than the lipase value of the second and third groups. The amylase value of the control group was significantly lower than all other groups. The highest Human Epididymis Protein 4 value was measured as 104 pmol/L in the first pancreatitis group, where the severity of pancreatitis was mild. CONCLUSIONS: In the present study, it was concluded that the Human Epididymis Protein 4 value increased in the case of mild pancreatitis, but there is no correlation between the severity of pancreatitis and the Human Epididymis Protein 4 value. Turkish Society of Gastroenterology 2023-06-01 /pmc/articles/PMC10441141/ /pubmed/37078202 http://dx.doi.org/10.5152/tjg.2023.22489 Text en © Copyright 2023 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Original Article
Acar, Ali
Ellidağ, Hamit Yaşar
Balaban, Kadir
Öcal, Serkan
Aslaner, Arif
Çakır, Tuğrul
Investigation of Serum Human Epididymitis Protein 4 Level in Rats with Experimental Acute Pancreatitis
title Investigation of Serum Human Epididymitis Protein 4 Level in Rats with Experimental Acute Pancreatitis
title_full Investigation of Serum Human Epididymitis Protein 4 Level in Rats with Experimental Acute Pancreatitis
title_fullStr Investigation of Serum Human Epididymitis Protein 4 Level in Rats with Experimental Acute Pancreatitis
title_full_unstemmed Investigation of Serum Human Epididymitis Protein 4 Level in Rats with Experimental Acute Pancreatitis
title_short Investigation of Serum Human Epididymitis Protein 4 Level in Rats with Experimental Acute Pancreatitis
title_sort investigation of serum human epididymitis protein 4 level in rats with experimental acute pancreatitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441141/
https://www.ncbi.nlm.nih.gov/pubmed/37078202
http://dx.doi.org/10.5152/tjg.2023.22489
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