Exosomal Long Non-coding RNAs Serve as Biomarkers for Liver Disease

Exosomes are tiny vesicles secreted by cells, with a diameter of 40-160 nm, which contain proteins, DNA, mRNA, long noncoding RNA, etc. Because of the low sensitivity and specificity of the conventional biomarkers for liver diseases, it is of utmost importance to discover novel, sensitive, specific,...

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Detalles Bibliográficos
Autores principales: Yang, Zixuan, Tang, Naping, Zheng, Minhui, Chang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Society of Gastroenterology 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441155/
https://www.ncbi.nlm.nih.gov/pubmed/37326156
http://dx.doi.org/10.5152/tjg.2023.22741
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author Yang, Zixuan
Tang, Naping
Zheng, Minhui
Chang, Yan
author_facet Yang, Zixuan
Tang, Naping
Zheng, Minhui
Chang, Yan
author_sort Yang, Zixuan
collection PubMed
description Exosomes are tiny vesicles secreted by cells, with a diameter of 40-160 nm, which contain proteins, DNA, mRNA, long noncoding RNA, etc. Because of the low sensitivity and specificity of the conventional biomarkers for liver diseases, it is of utmost importance to discover novel, sensitive, specific, and non-invasive biomarkers. Exosomal long noncoding RNAs have been considered as potential diagnostic, prognostic, or predictive biomarkers in a wide range of liver pathologies. In this review, we discuss the recent progress on exosomal long noncoding RNAs that serve as potential diagnostic, prognostic, or predictive markers and molecular targets in patients with hepatocellular carcinoma, cholestatic liver injury, viral hepatitis, and alcohol-related liver diseases.
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spelling pubmed-104411552023-08-22 Exosomal Long Non-coding RNAs Serve as Biomarkers for Liver Disease Yang, Zixuan Tang, Naping Zheng, Minhui Chang, Yan Turk J Gastroenterol Review Exosomes are tiny vesicles secreted by cells, with a diameter of 40-160 nm, which contain proteins, DNA, mRNA, long noncoding RNA, etc. Because of the low sensitivity and specificity of the conventional biomarkers for liver diseases, it is of utmost importance to discover novel, sensitive, specific, and non-invasive biomarkers. Exosomal long noncoding RNAs have been considered as potential diagnostic, prognostic, or predictive biomarkers in a wide range of liver pathologies. In this review, we discuss the recent progress on exosomal long noncoding RNAs that serve as potential diagnostic, prognostic, or predictive markers and molecular targets in patients with hepatocellular carcinoma, cholestatic liver injury, viral hepatitis, and alcohol-related liver diseases. Turkish Society of Gastroenterology 2023-07-01 /pmc/articles/PMC10441155/ /pubmed/37326156 http://dx.doi.org/10.5152/tjg.2023.22741 Text en © Copyright 2023 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Yang, Zixuan
Tang, Naping
Zheng, Minhui
Chang, Yan
Exosomal Long Non-coding RNAs Serve as Biomarkers for Liver Disease
title Exosomal Long Non-coding RNAs Serve as Biomarkers for Liver Disease
title_full Exosomal Long Non-coding RNAs Serve as Biomarkers for Liver Disease
title_fullStr Exosomal Long Non-coding RNAs Serve as Biomarkers for Liver Disease
title_full_unstemmed Exosomal Long Non-coding RNAs Serve as Biomarkers for Liver Disease
title_short Exosomal Long Non-coding RNAs Serve as Biomarkers for Liver Disease
title_sort exosomal long non-coding rnas serve as biomarkers for liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441155/
https://www.ncbi.nlm.nih.gov/pubmed/37326156
http://dx.doi.org/10.5152/tjg.2023.22741
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AT zhengminhui exosomallongnoncodingrnasserveasbiomarkersforliverdisease
AT changyan exosomallongnoncodingrnasserveasbiomarkersforliverdisease

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