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Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity
Obesity is a global and rising multifactorial pandemic associated with the emergence of several comorbidities that are risk factors for malignant cardiac remodeling and disease. High-intensity interval training (HIIT) has gained considerable attention due to its favorable outcomes of cardiometabolic...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441243/ https://www.ncbi.nlm.nih.gov/pubmed/37608837 http://dx.doi.org/10.3389/fphys.2023.1170324 |
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author | Bo, Bing Guo, Aijing Kaila, Severa Jafeth Hao, Zhe Zhang, Huiqing Wei, Jianshe Yao, Yuan |
author_facet | Bo, Bing Guo, Aijing Kaila, Severa Jafeth Hao, Zhe Zhang, Huiqing Wei, Jianshe Yao, Yuan |
author_sort | Bo, Bing |
collection | PubMed |
description | Obesity is a global and rising multifactorial pandemic associated with the emergence of several comorbidities that are risk factors for malignant cardiac remodeling and disease. High-intensity interval training (HIIT) has gained considerable attention due to its favorable outcomes of cardiometabolic health in individuals with overweight or obese. The primary aim of this review is to discuss the fundamental processes through which HIIT improves cardiac impairment in individuals with obesity to develop viable treatments for obesity management. In this review, a multiple database search and collection were conducted from the earliest record to January 2013 for studies included the qualitative component of HIIT intervention in humans and animals with overweight/obesity related to cardiac remodeling and fitness. We attempt to integrate the main mechanisms of HIIT in cardiac remolding improvement in obesity into an overall sequential hypothesis. This work focus on the ameliorative effects of HIIT on obesity-induced cardiac remodeling with respect to potential and pleiotropic mechanisms, including adipose distribution, energy metabolism, inflammatory response, insulin resistance, and related risk profiles in obesity. In conclusion, HIIT has been shown to reduce obesity-induced risks of cardiac remodeling, but the long-term effects of HIIT on obesity-induced cardiac injury and disease are presently unknown. Collective understanding highlights numerous specific research that are needed before the safety and effectiveness of HIIT can be confirmed and widely adopted in patient with obesity. |
format | Online Article Text |
id | pubmed-10441243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104412432023-08-22 Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity Bo, Bing Guo, Aijing Kaila, Severa Jafeth Hao, Zhe Zhang, Huiqing Wei, Jianshe Yao, Yuan Front Physiol Physiology Obesity is a global and rising multifactorial pandemic associated with the emergence of several comorbidities that are risk factors for malignant cardiac remodeling and disease. High-intensity interval training (HIIT) has gained considerable attention due to its favorable outcomes of cardiometabolic health in individuals with overweight or obese. The primary aim of this review is to discuss the fundamental processes through which HIIT improves cardiac impairment in individuals with obesity to develop viable treatments for obesity management. In this review, a multiple database search and collection were conducted from the earliest record to January 2013 for studies included the qualitative component of HIIT intervention in humans and animals with overweight/obesity related to cardiac remodeling and fitness. We attempt to integrate the main mechanisms of HIIT in cardiac remolding improvement in obesity into an overall sequential hypothesis. This work focus on the ameliorative effects of HIIT on obesity-induced cardiac remodeling with respect to potential and pleiotropic mechanisms, including adipose distribution, energy metabolism, inflammatory response, insulin resistance, and related risk profiles in obesity. In conclusion, HIIT has been shown to reduce obesity-induced risks of cardiac remodeling, but the long-term effects of HIIT on obesity-induced cardiac injury and disease are presently unknown. Collective understanding highlights numerous specific research that are needed before the safety and effectiveness of HIIT can be confirmed and widely adopted in patient with obesity. Frontiers Media S.A. 2023-08-07 /pmc/articles/PMC10441243/ /pubmed/37608837 http://dx.doi.org/10.3389/fphys.2023.1170324 Text en Copyright © 2023 Bo, Guo, Kaila, Hao, Zhang, Wei and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Bo, Bing Guo, Aijing Kaila, Severa Jafeth Hao, Zhe Zhang, Huiqing Wei, Jianshe Yao, Yuan Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity |
title | Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity |
title_full | Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity |
title_fullStr | Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity |
title_full_unstemmed | Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity |
title_short | Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity |
title_sort | elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441243/ https://www.ncbi.nlm.nih.gov/pubmed/37608837 http://dx.doi.org/10.3389/fphys.2023.1170324 |
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