Cargando…

Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity

Obesity is a global and rising multifactorial pandemic associated with the emergence of several comorbidities that are risk factors for malignant cardiac remodeling and disease. High-intensity interval training (HIIT) has gained considerable attention due to its favorable outcomes of cardiometabolic...

Descripción completa

Detalles Bibliográficos
Autores principales: Bo, Bing, Guo, Aijing, Kaila, Severa Jafeth, Hao, Zhe, Zhang, Huiqing, Wei, Jianshe, Yao, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441243/
https://www.ncbi.nlm.nih.gov/pubmed/37608837
http://dx.doi.org/10.3389/fphys.2023.1170324
_version_ 1785093341715628032
author Bo, Bing
Guo, Aijing
Kaila, Severa Jafeth
Hao, Zhe
Zhang, Huiqing
Wei, Jianshe
Yao, Yuan
author_facet Bo, Bing
Guo, Aijing
Kaila, Severa Jafeth
Hao, Zhe
Zhang, Huiqing
Wei, Jianshe
Yao, Yuan
author_sort Bo, Bing
collection PubMed
description Obesity is a global and rising multifactorial pandemic associated with the emergence of several comorbidities that are risk factors for malignant cardiac remodeling and disease. High-intensity interval training (HIIT) has gained considerable attention due to its favorable outcomes of cardiometabolic health in individuals with overweight or obese. The primary aim of this review is to discuss the fundamental processes through which HIIT improves cardiac impairment in individuals with obesity to develop viable treatments for obesity management. In this review, a multiple database search and collection were conducted from the earliest record to January 2013 for studies included the qualitative component of HIIT intervention in humans and animals with overweight/obesity related to cardiac remodeling and fitness. We attempt to integrate the main mechanisms of HIIT in cardiac remolding improvement in obesity into an overall sequential hypothesis. This work focus on the ameliorative effects of HIIT on obesity-induced cardiac remodeling with respect to potential and pleiotropic mechanisms, including adipose distribution, energy metabolism, inflammatory response, insulin resistance, and related risk profiles in obesity. In conclusion, HIIT has been shown to reduce obesity-induced risks of cardiac remodeling, but the long-term effects of HIIT on obesity-induced cardiac injury and disease are presently unknown. Collective understanding highlights numerous specific research that are needed before the safety and effectiveness of HIIT can be confirmed and widely adopted in patient with obesity.
format Online
Article
Text
id pubmed-10441243
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-104412432023-08-22 Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity Bo, Bing Guo, Aijing Kaila, Severa Jafeth Hao, Zhe Zhang, Huiqing Wei, Jianshe Yao, Yuan Front Physiol Physiology Obesity is a global and rising multifactorial pandemic associated with the emergence of several comorbidities that are risk factors for malignant cardiac remodeling and disease. High-intensity interval training (HIIT) has gained considerable attention due to its favorable outcomes of cardiometabolic health in individuals with overweight or obese. The primary aim of this review is to discuss the fundamental processes through which HIIT improves cardiac impairment in individuals with obesity to develop viable treatments for obesity management. In this review, a multiple database search and collection were conducted from the earliest record to January 2013 for studies included the qualitative component of HIIT intervention in humans and animals with overweight/obesity related to cardiac remodeling and fitness. We attempt to integrate the main mechanisms of HIIT in cardiac remolding improvement in obesity into an overall sequential hypothesis. This work focus on the ameliorative effects of HIIT on obesity-induced cardiac remodeling with respect to potential and pleiotropic mechanisms, including adipose distribution, energy metabolism, inflammatory response, insulin resistance, and related risk profiles in obesity. In conclusion, HIIT has been shown to reduce obesity-induced risks of cardiac remodeling, but the long-term effects of HIIT on obesity-induced cardiac injury and disease are presently unknown. Collective understanding highlights numerous specific research that are needed before the safety and effectiveness of HIIT can be confirmed and widely adopted in patient with obesity. Frontiers Media S.A. 2023-08-07 /pmc/articles/PMC10441243/ /pubmed/37608837 http://dx.doi.org/10.3389/fphys.2023.1170324 Text en Copyright © 2023 Bo, Guo, Kaila, Hao, Zhang, Wei and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Bo, Bing
Guo, Aijing
Kaila, Severa Jafeth
Hao, Zhe
Zhang, Huiqing
Wei, Jianshe
Yao, Yuan
Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity
title Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity
title_full Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity
title_fullStr Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity
title_full_unstemmed Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity
title_short Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity
title_sort elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441243/
https://www.ncbi.nlm.nih.gov/pubmed/37608837
http://dx.doi.org/10.3389/fphys.2023.1170324
work_keys_str_mv AT bobing elucidatingtheprimarymechanismsofhighintensityintervaltrainingforimprovedcardiacfitnessinobesity
AT guoaijing elucidatingtheprimarymechanismsofhighintensityintervaltrainingforimprovedcardiacfitnessinobesity
AT kailaseverajafeth elucidatingtheprimarymechanismsofhighintensityintervaltrainingforimprovedcardiacfitnessinobesity
AT haozhe elucidatingtheprimarymechanismsofhighintensityintervaltrainingforimprovedcardiacfitnessinobesity
AT zhanghuiqing elucidatingtheprimarymechanismsofhighintensityintervaltrainingforimprovedcardiacfitnessinobesity
AT weijianshe elucidatingtheprimarymechanismsofhighintensityintervaltrainingforimprovedcardiacfitnessinobesity
AT yaoyuan elucidatingtheprimarymechanismsofhighintensityintervaltrainingforimprovedcardiacfitnessinobesity