Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C(+/−) During Development

Hypertrophic cardiomyopathy (HCM) is one of the most common heritable cardiovascular diseases and variants of TNNT2 (cardiac troponin T) are linked to increased risk of sudden cardiac arrest despite causing limited hypertrophy. In this study, a TNNT2 variant, R278C(+/−), was generated in both human...

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Detalles Bibliográficos
Autores principales: Shafaattalab, Sanam, Li, Alison Y, Jayousi, Farah, Maaref, Yasaman, Dababneh, Saif, Hamledari, Homa, Baygi, Dina Hosseini, Barszczewski, Tiffany, Ruprai, Balwinder, Jannati, Shayan, Nagalingam, Raghu, Cool, Austin M, Langa, Paulina, Chiao, Mu, Roston, Thomas, Solaro, R John, Sanatani, Shubhayan, Toepfer, Christopher, Lindert, Steffen, Lange, Philipp, Tibbits, Glen F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441323/
https://www.ncbi.nlm.nih.gov/pubmed/37609317
http://dx.doi.org/10.1101/2023.06.06.542948

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