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Gas tunnel engineering of prolyl hydroxylase reprograms hypoxia signaling in cells

Molecular engineering of biocatalysts has revolutionized complex synthetic chemistry and sustainable catalysis. Here, we show that it is also possible to use engineered biocatalysts to reprogram signal transduction in human cells. More specifically, we manipulate cellular hypoxia (low O(2)) signalin...

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Detalles Bibliográficos
Autores principales:	Windsor, Peter, Ouyang, Haiping, da Costa, Joseph A. G., Damodaran, Anoop Rama, Chen, Yue, Bhagi-Damodaran, Ambika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441328/ https://www.ncbi.nlm.nih.gov/pubmed/37609209 http://dx.doi.org/10.1101/2023.08.07.552357

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