Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) Protein and CXCL11 Chemokine Boosts Antiviral Local Tissue-Resident and Effector Memory CD4(+) and CD8(+) T Cells and Protects Against Recurrent Genital Herpes

Following acute herpes simplex virus type 2 (HSV-2) infection, the virus undergoes latency in sensory neurons of the dorsal root ganglia (DRG). Intermittent virus reactivation from latency and shedding in the vaginal mucosa (VM) causes recurrent genital herpes. While T-cells appear to play a role in...

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Detalles Bibliográficos
Autores principales: Quadiri, Afshana, Prakash, Swayam, Dhanushkodi, Nisha Rajeswari, Singer, Mahmoud, Zayou, Latifa, Shaik, Amin Mohammed, Sun, Miyo, Suzer, Berfin, Lau, Lauren, Chilukurri, Amruth, Vahed, Hawa, Schaefer, Hubert, BenMohamed, Lbachir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441333/
https://www.ncbi.nlm.nih.gov/pubmed/37609157
http://dx.doi.org/10.1101/2023.08.08.552454

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