Crohn’s patients and healthy infants share immunodominant B cell response to commensal flagellin peptide epitopes

About half of patients with Crohn’s disease (CD) develop selective serum IgG response to flagellin proteins of the Lachnospiraceae family. Here, we identified a dominant B cell peptide epitope in CD, locating in the highly conserved “hinge region” between the D0 and D1 domains at the amino-terminus...

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Detalles Bibliográficos
Autores principales: Zhao, Qing, Duck, Lennard Wayne, Killian, John T., Rosenberg, Alexander F., Mannon, Peter J., King, R. Glenn, Denson, Lee A., Kugathasan, Subra, Janoff, Edward N., Jenmalm, Maria C., Elson, Charles O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441350/
https://www.ncbi.nlm.nih.gov/pubmed/37609309
http://dx.doi.org/10.1101/2023.08.08.552496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441350/
https://www.ncbi.nlm.nih.gov/pubmed/37609309
http://dx.doi.org/10.1101/2023.08.08.552496

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