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Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors

Errors in mitosis can generate micronuclei that entrap mis-segregated chromosomes, which are susceptible to catastrophic fragmentation through a process termed chromothripsis. The reassembly of fragmented chromosomes by error-prone DNA double-strand break (DSB) repair generates a spectrum of simple...

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Detalles Bibliográficos
Autores principales:	Hu, Qing, Valle-Inclan, Jose Espejo, Dahiya, Rashmi, Guyer, Alison, Mazzagatti, Alice, Maurais, Elizabeth G., Engel, Justin L., Cortés-Ciriano, Isidro, Ly, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441393/ https://www.ncbi.nlm.nih.gov/pubmed/37609143 http://dx.doi.org/10.1101/2023.08.10.552800

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