Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function

The human CMG helicase (Cdc45-MCM-GINS) is a novel target for anti-cancer therapy due to tumor-specific weaknesses in CMG function induced by oncogenic changes and the need for CMG function during recovery from replicative stresses such as chemotherapy. Here, we developed an orthogonal biochemical s...

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Detalles Bibliográficos
Autores principales: Xiang, Shengyan, Luo, Xingju, Welch, Darcy, Reed, Damon R., Alexandrow, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441460/
https://www.ncbi.nlm.nih.gov/pubmed/37609279
http://dx.doi.org/10.21203/rs.3.rs-3182731/v1

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