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Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age

INTRODUCTION: The association of 2-year neurodevelopmental and behavioral outcomes with in-hospital or post-discharge growth failure (GF) using contemporary definitions for preterm infants is unknown. METHODS: In a secondary analysis of a preterm cohort, changes in anthropometric z-scores were exami...

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Autores principales: Strobel, Katie, Wood, Thomas, Valentine, Gregory, German, Kendell, Gogcu, Semsa, Hendrixson, D, Kolnik, Sarah, Law, Janessa, Mayock, Dennis, Comstock, Bryan, Heagerty, Patrick, Juul, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441482/
https://www.ncbi.nlm.nih.gov/pubmed/37609333
http://dx.doi.org/10.21203/rs.3.rs-3228742/v1
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author Strobel, Katie
Wood, Thomas
Valentine, Gregory
German, Kendell
Gogcu, Semsa
Hendrixson, D
Kolnik, Sarah
Law, Janessa
Mayock, Dennis
Comstock, Bryan
Heagerty, Patrick
Juul, Sandra
author_facet Strobel, Katie
Wood, Thomas
Valentine, Gregory
German, Kendell
Gogcu, Semsa
Hendrixson, D
Kolnik, Sarah
Law, Janessa
Mayock, Dennis
Comstock, Bryan
Heagerty, Patrick
Juul, Sandra
author_sort Strobel, Katie
collection PubMed
description INTRODUCTION: The association of 2-year neurodevelopmental and behavioral outcomes with in-hospital or post-discharge growth failure (GF) using contemporary definitions for preterm infants is unknown. METHODS: In a secondary analysis of a preterm cohort, changes in anthropometric z-scores were examined between birth and hospital discharge, and from discharge to 2 years. The 2-year evaluation included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist (CBCL). RESULTS: Among 629 infants, accelerated linear growth from birth to discharge was associated with higher BSID-III cognitive scores (+ 3.2 points [IQR 0.02, 6.4]) while in-hospital GF was not associated with any outcomes. Infants with weight GF after discharge had lower BSID-III motor scores (−3.1 points [−5.9, −0.2]). Infants with accelerated weight growth after discharge had increased odds of behavioral problems on the CBCL (aOR 1.9 [1.03, 3.5]). DISCUSSION: In-hospital and post-hospitalization growth metrics are modestly associated with neurodevelopmental outcomes with length gains apparently most beneficial.
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spelling pubmed-104414822023-08-22 Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age Strobel, Katie Wood, Thomas Valentine, Gregory German, Kendell Gogcu, Semsa Hendrixson, D Kolnik, Sarah Law, Janessa Mayock, Dennis Comstock, Bryan Heagerty, Patrick Juul, Sandra Res Sq Article INTRODUCTION: The association of 2-year neurodevelopmental and behavioral outcomes with in-hospital or post-discharge growth failure (GF) using contemporary definitions for preterm infants is unknown. METHODS: In a secondary analysis of a preterm cohort, changes in anthropometric z-scores were examined between birth and hospital discharge, and from discharge to 2 years. The 2-year evaluation included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist (CBCL). RESULTS: Among 629 infants, accelerated linear growth from birth to discharge was associated with higher BSID-III cognitive scores (+ 3.2 points [IQR 0.02, 6.4]) while in-hospital GF was not associated with any outcomes. Infants with weight GF after discharge had lower BSID-III motor scores (−3.1 points [−5.9, −0.2]). Infants with accelerated weight growth after discharge had increased odds of behavioral problems on the CBCL (aOR 1.9 [1.03, 3.5]). DISCUSSION: In-hospital and post-hospitalization growth metrics are modestly associated with neurodevelopmental outcomes with length gains apparently most beneficial. American Journal Experts 2023-08-09 /pmc/articles/PMC10441482/ /pubmed/37609333 http://dx.doi.org/10.21203/rs.3.rs-3228742/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Strobel, Katie
Wood, Thomas
Valentine, Gregory
German, Kendell
Gogcu, Semsa
Hendrixson, D
Kolnik, Sarah
Law, Janessa
Mayock, Dennis
Comstock, Bryan
Heagerty, Patrick
Juul, Sandra
Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age
title Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age
title_full Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age
title_fullStr Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age
title_full_unstemmed Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age
title_short Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age
title_sort contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441482/
https://www.ncbi.nlm.nih.gov/pubmed/37609333
http://dx.doi.org/10.21203/rs.3.rs-3228742/v1
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