Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection

BACKGROUND: Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. METHODS: We investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs...

Descripción completa

Detalles Bibliográficos
Autores principales: Selvavinayagam, Sivaprakasam T, Aswathy, Bijulal, Yong, Yean K, Frederick, Asha, Murali, Lakshmi, Kalaivani, Vasudevan, Jith, Karishma S, Rajeshkumar, Manivannan, Anusree, Adukkadukkam, Kannan, Meganathan, Gopalan, Natarajan, Vignesh, Ramachandran, Murugesan, Amudhan, Tan, Hong Yien, Zhang, Ying, Chandramathi, Samudi, Sivasankaran, Munusamy Ponnan, Govindaraj, Sakthivel, Byrareddy, Siddappa N, Velu, Vijayakumar, Larsson, Marie, Shankar, Esaki M, Raju, Sivadoss
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441491/
https://www.ncbi.nlm.nih.gov/pubmed/37609153
http://dx.doi.org/10.1101/2023.08.07.23293767
Descripción
Sumario:BACKGROUND: Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. METHODS: We investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. We also measured the plasma cytokines using a commercial Bio-Plex Pro Human Cytokine 17-plex assay. RESULTS: Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. CONCLUSIONS: We postulated that CXCL8 and MCP-1 could be the surrogate biomarkers of LTBI, especially in resource-limited settings.

Ejemplares similares