Cargando…
Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection
BACKGROUND: Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. METHODS: We investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441491/ https://www.ncbi.nlm.nih.gov/pubmed/37609153 http://dx.doi.org/10.1101/2023.08.07.23293767 |
| _version_ | 1785093385582804992 |
|---|---|
| author | Selvavinayagam, Sivaprakasam T Aswathy, Bijulal Yong, Yean K Frederick, Asha Murali, Lakshmi Kalaivani, Vasudevan Jith, Karishma S Rajeshkumar, Manivannan Anusree, Adukkadukkam Kannan, Meganathan Gopalan, Natarajan Vignesh, Ramachandran Murugesan, Amudhan Tan, Hong Yien Zhang, Ying Chandramathi, Samudi Sivasankaran, Munusamy Ponnan Govindaraj, Sakthivel Byrareddy, Siddappa N Velu, Vijayakumar Larsson, Marie Shankar, Esaki M Raju, Sivadoss |
| author_facet | Selvavinayagam, Sivaprakasam T Aswathy, Bijulal Yong, Yean K Frederick, Asha Murali, Lakshmi Kalaivani, Vasudevan Jith, Karishma S Rajeshkumar, Manivannan Anusree, Adukkadukkam Kannan, Meganathan Gopalan, Natarajan Vignesh, Ramachandran Murugesan, Amudhan Tan, Hong Yien Zhang, Ying Chandramathi, Samudi Sivasankaran, Munusamy Ponnan Govindaraj, Sakthivel Byrareddy, Siddappa N Velu, Vijayakumar Larsson, Marie Shankar, Esaki M Raju, Sivadoss |
| author_sort | Selvavinayagam, Sivaprakasam T |
| collection | PubMed |
| description | BACKGROUND: Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. METHODS: We investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. We also measured the plasma cytokines using a commercial Bio-Plex Pro Human Cytokine 17-plex assay. RESULTS: Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. CONCLUSIONS: We postulated that CXCL8 and MCP-1 could be the surrogate biomarkers of LTBI, especially in resource-limited settings. |
| format | Online Article Text |
| id | pubmed-10441491 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Cold Spring Harbor Laboratory |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104414912023-08-22 Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection Selvavinayagam, Sivaprakasam T Aswathy, Bijulal Yong, Yean K Frederick, Asha Murali, Lakshmi Kalaivani, Vasudevan Jith, Karishma S Rajeshkumar, Manivannan Anusree, Adukkadukkam Kannan, Meganathan Gopalan, Natarajan Vignesh, Ramachandran Murugesan, Amudhan Tan, Hong Yien Zhang, Ying Chandramathi, Samudi Sivasankaran, Munusamy Ponnan Govindaraj, Sakthivel Byrareddy, Siddappa N Velu, Vijayakumar Larsson, Marie Shankar, Esaki M Raju, Sivadoss medRxiv Article BACKGROUND: Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. METHODS: We investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. We also measured the plasma cytokines using a commercial Bio-Plex Pro Human Cytokine 17-plex assay. RESULTS: Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. CONCLUSIONS: We postulated that CXCL8 and MCP-1 could be the surrogate biomarkers of LTBI, especially in resource-limited settings. Cold Spring Harbor Laboratory 2023-08-09 /pmc/articles/PMC10441491/ /pubmed/37609153 http://dx.doi.org/10.1101/2023.08.07.23293767 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
| spellingShingle | Article Selvavinayagam, Sivaprakasam T Aswathy, Bijulal Yong, Yean K Frederick, Asha Murali, Lakshmi Kalaivani, Vasudevan Jith, Karishma S Rajeshkumar, Manivannan Anusree, Adukkadukkam Kannan, Meganathan Gopalan, Natarajan Vignesh, Ramachandran Murugesan, Amudhan Tan, Hong Yien Zhang, Ying Chandramathi, Samudi Sivasankaran, Munusamy Ponnan Govindaraj, Sakthivel Byrareddy, Siddappa N Velu, Vijayakumar Larsson, Marie Shankar, Esaki M Raju, Sivadoss Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection |
| title | Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection |
| title_full | Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection |
| title_fullStr | Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection |
| title_full_unstemmed | Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection |
| title_short | Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection |
| title_sort | plasma cxcl8 and mcp-1 as biomarkers of latent tuberculosis infection |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441491/ https://www.ncbi.nlm.nih.gov/pubmed/37609153 http://dx.doi.org/10.1101/2023.08.07.23293767 |
| work_keys_str_mv | AT selvavinayagamsivaprakasamt plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT aswathybijulal plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT yongyeank plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT frederickasha plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT muralilakshmi plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT kalaivanivasudevan plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT jithkarishmas plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT rajeshkumarmanivannan plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT anusreeadukkadukkam plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT kannanmeganathan plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT gopalannatarajan plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT vigneshramachandran plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT murugesanamudhan plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT tanhongyien plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT zhangying plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT chandramathisamudi plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT sivasankaranmunusamyponnan plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT govindarajsakthivel plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT byrareddysiddappan plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT veluvijayakumar plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT larssonmarie plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT shankaresakim plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection AT rajusivadoss plasmacxcl8andmcp1asbiomarkersoflatenttuberculosisinfection |