Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn

During mouse embryogenesis, expression of the long non-coding RNA (lncRNA) Airn leads to gene repression and recruitment of Polycomb repressive complexes (PRCs) to varying extents over a 15-Mb domain. The mechanisms remain unclear. Using high-resolution approaches, we show in mouse trophoblast stem...

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Detalles Bibliográficos
Autores principales: Braceros, Aki K., Schertzer, Megan D., Omer, Arina, Trotman, Jackson B., Davis, Eric S., Dowen, Jill M., Phanstiel, Douglas H., Aiden, Erez Lieberman, Calabrese, J. Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441531/
https://www.ncbi.nlm.nih.gov/pubmed/37436897
http://dx.doi.org/10.1016/j.celrep.2023.112803

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