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Influence of Trabeculectomy with Mitomycin C on Longitudinal Changes in the Visual Field in Glaucoma Patients with High Myopia

PURPOSE: To evaluate the effect of trabeculectomy (Trab MMC) on visual field (VF) progression in eyes with glaucoma and high myopia. PATIENTS AND METHODS: Patients diagnosed with primary open-angle glaucoma or exfoliation glaucoma who underwent Trab MMC as the first glaucoma surgery along with ≥3 VF...

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Autores principales: Yamagata, Yutaro, Suda, Kenji, Akagi, Tadamichi, Ikeda, Hanako Ohashi, Kameda, Takanori, Hasegawa, Tomoko, Miyake, Masahiro, Tsujikawa, Akitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441649/
https://www.ncbi.nlm.nih.gov/pubmed/37609644
http://dx.doi.org/10.2147/OPTH.S415654
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author Yamagata, Yutaro
Suda, Kenji
Akagi, Tadamichi
Ikeda, Hanako Ohashi
Kameda, Takanori
Hasegawa, Tomoko
Miyake, Masahiro
Tsujikawa, Akitaka
author_facet Yamagata, Yutaro
Suda, Kenji
Akagi, Tadamichi
Ikeda, Hanako Ohashi
Kameda, Takanori
Hasegawa, Tomoko
Miyake, Masahiro
Tsujikawa, Akitaka
author_sort Yamagata, Yutaro
collection PubMed
description PURPOSE: To evaluate the effect of trabeculectomy (Trab MMC) on visual field (VF) progression in eyes with glaucoma and high myopia. PATIENTS AND METHODS: Patients diagnosed with primary open-angle glaucoma or exfoliation glaucoma who underwent Trab MMC as the first glaucoma surgery along with ≥3 VF tests preoperatively and postoperatively were enrolled. High myopia was defined as an axial length ≥26.5 mm. Postoperative reductions in intraocular pressure (IOP) were assessed by survival analysis using IOP measurements obtained preoperatively. The longitudinal trends of the outcome measures were evaluated using linear mixed models. RESULTS: Thirty-five eyes of 32 patients were included in this study, including 22 eyes of 20 patients in non-highly myopic group and 13 eyes of 12 patients in highly myopic group. IOP decreased after Trab MMC, and the survival rate did not differ significantly in relation to axial length. Linear mixed-model analyses suggested that the inhibitory effects of Trab MMC on the rate of mean deviation (MD) changes were significant in the non-highly myopic group (−0.53 ± 0.15 dB/year preoperatively to −0.16 ± 0.13 dB/year postoperatively; P = 0.004), but not in the highly myopic group (−0.66 ± 0.19 dB/year preoperatively to −0.48 ± 0.18 dB/year postoperatively; P = 0.32). CONCLUSION: Trab MMC reduced IOP in both highly myopic and non-highly myopic eyes, and IOP reduction was very similar in both groups. The VF deterioration rate decreased in both groups, but the change was weaker and nonsignificant in the highly myopic group.
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spelling pubmed-104416492023-08-22 Influence of Trabeculectomy with Mitomycin C on Longitudinal Changes in the Visual Field in Glaucoma Patients with High Myopia Yamagata, Yutaro Suda, Kenji Akagi, Tadamichi Ikeda, Hanako Ohashi Kameda, Takanori Hasegawa, Tomoko Miyake, Masahiro Tsujikawa, Akitaka Clin Ophthalmol Original Research PURPOSE: To evaluate the effect of trabeculectomy (Trab MMC) on visual field (VF) progression in eyes with glaucoma and high myopia. PATIENTS AND METHODS: Patients diagnosed with primary open-angle glaucoma or exfoliation glaucoma who underwent Trab MMC as the first glaucoma surgery along with ≥3 VF tests preoperatively and postoperatively were enrolled. High myopia was defined as an axial length ≥26.5 mm. Postoperative reductions in intraocular pressure (IOP) were assessed by survival analysis using IOP measurements obtained preoperatively. The longitudinal trends of the outcome measures were evaluated using linear mixed models. RESULTS: Thirty-five eyes of 32 patients were included in this study, including 22 eyes of 20 patients in non-highly myopic group and 13 eyes of 12 patients in highly myopic group. IOP decreased after Trab MMC, and the survival rate did not differ significantly in relation to axial length. Linear mixed-model analyses suggested that the inhibitory effects of Trab MMC on the rate of mean deviation (MD) changes were significant in the non-highly myopic group (−0.53 ± 0.15 dB/year preoperatively to −0.16 ± 0.13 dB/year postoperatively; P = 0.004), but not in the highly myopic group (−0.66 ± 0.19 dB/year preoperatively to −0.48 ± 0.18 dB/year postoperatively; P = 0.32). CONCLUSION: Trab MMC reduced IOP in both highly myopic and non-highly myopic eyes, and IOP reduction was very similar in both groups. The VF deterioration rate decreased in both groups, but the change was weaker and nonsignificant in the highly myopic group. Dove 2023-08-17 /pmc/articles/PMC10441649/ /pubmed/37609644 http://dx.doi.org/10.2147/OPTH.S415654 Text en © 2023 Yamagata et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Yamagata, Yutaro
Suda, Kenji
Akagi, Tadamichi
Ikeda, Hanako Ohashi
Kameda, Takanori
Hasegawa, Tomoko
Miyake, Masahiro
Tsujikawa, Akitaka
Influence of Trabeculectomy with Mitomycin C on Longitudinal Changes in the Visual Field in Glaucoma Patients with High Myopia
title Influence of Trabeculectomy with Mitomycin C on Longitudinal Changes in the Visual Field in Glaucoma Patients with High Myopia
title_full Influence of Trabeculectomy with Mitomycin C on Longitudinal Changes in the Visual Field in Glaucoma Patients with High Myopia
title_fullStr Influence of Trabeculectomy with Mitomycin C on Longitudinal Changes in the Visual Field in Glaucoma Patients with High Myopia
title_full_unstemmed Influence of Trabeculectomy with Mitomycin C on Longitudinal Changes in the Visual Field in Glaucoma Patients with High Myopia
title_short Influence of Trabeculectomy with Mitomycin C on Longitudinal Changes in the Visual Field in Glaucoma Patients with High Myopia
title_sort influence of trabeculectomy with mitomycin c on longitudinal changes in the visual field in glaucoma patients with high myopia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441649/
https://www.ncbi.nlm.nih.gov/pubmed/37609644
http://dx.doi.org/10.2147/OPTH.S415654
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