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Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial

INTRODUCTION: Treatments for AGA have yet to produce satisfactory outcomes and may cause intolerable side effects. Recent studies have reported that adipose tissue-derived stem cell conditioned media (ADSC-CM) could induce hair growth and regeneration. OBJECTIVE: To investigate the efficacy of ADSC-...

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Autores principales: Legiawati, Lili, Suseno, Lis Surachmiati, Sitohang, Irma Bernadette S., Yusharyahya, Shannaz Nadia, Pawitan, Jeanne Adiwinata, Liem, Isabella Kurnia, Kurniawati, Trie, Ardelia, Athaya, Paramastri, Kanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441691/
https://www.ncbi.nlm.nih.gov/pubmed/37605227
http://dx.doi.org/10.1186/s13287-023-03440-2
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author Legiawati, Lili
Suseno, Lis Surachmiati
Sitohang, Irma Bernadette S.
Yusharyahya, Shannaz Nadia
Pawitan, Jeanne Adiwinata
Liem, Isabella Kurnia
Kurniawati, Trie
Ardelia, Athaya
Paramastri, Kanya
author_facet Legiawati, Lili
Suseno, Lis Surachmiati
Sitohang, Irma Bernadette S.
Yusharyahya, Shannaz Nadia
Pawitan, Jeanne Adiwinata
Liem, Isabella Kurnia
Kurniawati, Trie
Ardelia, Athaya
Paramastri, Kanya
author_sort Legiawati, Lili
collection PubMed
description INTRODUCTION: Treatments for AGA have yet to produce satisfactory outcomes and may cause intolerable side effects. Recent studies have reported that adipose tissue-derived stem cell conditioned media (ADSC-CM) could induce hair growth and regeneration. OBJECTIVE: To investigate the efficacy of ADSC-CM combined with minoxidil for hair regeneration therapy in male AGA. METHODS: This study lasted for 6 weeks. Subjects were divided into two groups: concentrated and non-concentrated ADSC-CM. Scalp was divided vertically in half before intradermal injection was administered from the frontal region of the scalp toward the vertex with a 30G needle, spaced about 1 cm apart. Treatment side received 2 ml of ADSC-CM; the other side was given 2 ml of NaCl 0.9% as placebo. Patients applied 5% minoxidil twice daily post-injection. Improvements were assessed using photographs and trichoscan every 2 weeks. RESULTS: Hair count, hair density, and mean thickness increased significantly on both sides after 6 weeks, while vellus rate decreased proportionally with the increase of terminal rate. No statistically significant differences between treatment groups were found. Minimum side effects were reported, and subjects were satisfied with the results. CONCLUSION: Combination of ADSC-CM and minoxidil could be a potential agent for hair regrowth. Follow-up research with extensive populations, longer duration, and different study design may be required to confirm the exact mechanisms of ADSC-CM on hair growth. Trial registration: Clinicaltrials.gov, NCT05296863. Registered 25 March 2022—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05296863. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13287-023-03440-2.
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spelling pubmed-104416912023-08-22 Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial Legiawati, Lili Suseno, Lis Surachmiati Sitohang, Irma Bernadette S. Yusharyahya, Shannaz Nadia Pawitan, Jeanne Adiwinata Liem, Isabella Kurnia Kurniawati, Trie Ardelia, Athaya Paramastri, Kanya Stem Cell Res Ther Research INTRODUCTION: Treatments for AGA have yet to produce satisfactory outcomes and may cause intolerable side effects. Recent studies have reported that adipose tissue-derived stem cell conditioned media (ADSC-CM) could induce hair growth and regeneration. OBJECTIVE: To investigate the efficacy of ADSC-CM combined with minoxidil for hair regeneration therapy in male AGA. METHODS: This study lasted for 6 weeks. Subjects were divided into two groups: concentrated and non-concentrated ADSC-CM. Scalp was divided vertically in half before intradermal injection was administered from the frontal region of the scalp toward the vertex with a 30G needle, spaced about 1 cm apart. Treatment side received 2 ml of ADSC-CM; the other side was given 2 ml of NaCl 0.9% as placebo. Patients applied 5% minoxidil twice daily post-injection. Improvements were assessed using photographs and trichoscan every 2 weeks. RESULTS: Hair count, hair density, and mean thickness increased significantly on both sides after 6 weeks, while vellus rate decreased proportionally with the increase of terminal rate. No statistically significant differences between treatment groups were found. Minimum side effects were reported, and subjects were satisfied with the results. CONCLUSION: Combination of ADSC-CM and minoxidil could be a potential agent for hair regrowth. Follow-up research with extensive populations, longer duration, and different study design may be required to confirm the exact mechanisms of ADSC-CM on hair growth. Trial registration: Clinicaltrials.gov, NCT05296863. Registered 25 March 2022—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05296863. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13287-023-03440-2. BioMed Central 2023-08-21 /pmc/articles/PMC10441691/ /pubmed/37605227 http://dx.doi.org/10.1186/s13287-023-03440-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Legiawati, Lili
Suseno, Lis Surachmiati
Sitohang, Irma Bernadette S.
Yusharyahya, Shannaz Nadia
Pawitan, Jeanne Adiwinata
Liem, Isabella Kurnia
Kurniawati, Trie
Ardelia, Athaya
Paramastri, Kanya
Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial
title Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial
title_full Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial
title_fullStr Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial
title_full_unstemmed Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial
title_short Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial
title_sort combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441691/
https://www.ncbi.nlm.nih.gov/pubmed/37605227
http://dx.doi.org/10.1186/s13287-023-03440-2
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