Cargando…

Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8(+) T cells to demote the antitumor immunity

BACKGROUND: Variated anti-cancer therapies are combined with immune checkpoint blockades (ICBs) for improving ICB therapeutic efficacy. Occurrence of tissue damage is common that triggers multiple inflammatory cytokine generation. Gastrointestinal organs are the commonly affected. We investigated th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ruochan, Chen, Kun, Gong, Caifeng, Wu, Zhiyuan, Xu, Chungui, Li, Xing-Ning, Zhao, Fei, Wang, Dongmei, Cai, Jianqiang, Zhou, Aiping, Qu, Chunfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441727/ https://www.ncbi.nlm.nih.gov/pubmed/37605139 http://dx.doi.org/10.1186/s12916-023-03026-y

Ejemplares similares

AP-2 gets demoted
por: Dove, Alan W.
Publicado: (2003)

Sex Differences in Genomic Features of Hepatitis B–Associated Hepatocellular Carcinoma With Distinct Antitumor Immunity
por: Xu, Chungui, et al.
Publicado: (2022)

Occult infection with hepatitis B virus PreS variants synergistically promotes hepatocellular carcinoma development in a high-fat diet context by generating abnormal ceramides
por: Liu, Chang, et al.
Publicado: (2022)

Health promoting and demoting consumption: What accounts for budget share differentials by ethnicity in New Zealand
por: Nghiem, Nhung, et al.
Publicado: (2022)

Promote or Demote? Investigating the Impacts of China’s Transferable Development Rights Program on Farmers’ Income: A Case Study from Chongqing
por: Cheng, Long, et al.
Publicado: (2022)

Critical Role of TCF-1 in Repression of the IL-17 Gene
por: Ma, Jian, et al.
Publicado: (2011)

Helicobacter pylori Infection Promotes Gastric Premalignancies and Malignancies Lesions and Demotes Hyperplastic Polyps: A 5 Year Multicentric Study among Cameroonian Dyspeptic Patients
por: Nintewoue, Ghislaine Florice Faujo, et al.
Publicado: (2023)

PD-1 restrains IL-17A production from γδ T cells to modulate acute radiation-induced lung injury
por: Sheng, Yuling, et al.
Publicado: (2021)

ZnO-dotted porous ZnS cluster microspheres for high efficient, Pt-free photocatalytic hydrogen evolution
por: Wu, Aiping, et al.
Publicado: (2015)

Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer
por: Chen, Zheng, et al.
Publicado: (2023)

Elevated Pretherapy Serum IL17 in Primary Hepatocellular Carcinoma Patients Correlate to Increased Risk of Early Recurrence after Curative Hepatectomy
por: Wu, Jianxiong, et al.
Publicado: (2012)

IL-22 inhibits bleomycin-induced pulmonary fibrosis in association with inhibition of IL-17A in mice
por: Qu, Ziye, et al.
Publicado: (2022)

EPDR1 correlates with immune cell infiltration in hepatocellular carcinoma and can be used as a prognostic biomarker
por: Chen, Ruochan, et al.
Publicado: (2020)

T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications
por: Chi, Xiaoxia, et al.
Publicado: (2023)

DFNA5 regulates immune cells infiltration and exhaustion
por: Hu, Jian, et al.
Publicado: (2022)

IL-17RA-Signaling Modulates CD8+ T Cell Survival and Exhaustion During Trypanosoma cruzi Infection
por: Tosello Boari, Jimena, et al.
Publicado: (2018)

Lysophosphatidylcholine aggravates contact hypersensitivity by promoting neutrophil infiltration and IL17 expression
por: Song, Mi Hye, et al.
Publicado: (2021)

Early Fertilization Abnormalities in the Human: An Exhausted Area of Research?
por: Rosenbusch, Bernd
Publicado: (2017)

Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice
por: Jung, Hahn Jin, et al.
Publicado: (2021)

IL-17A Expression Is Localised to Both Mononuclear and Polymorphonuclear Synovial Cell Infiltrates
por: Moran, Ellen M., et al.
Publicado: (2011)

Prognostic biomarker IL17A correlated with immune infiltrates in head and neck cancer
por: Yu, Meng, et al.
Publicado: (2022)

Serum Concentration of CD137 and Tumor Infiltration by M1 Macrophages Predict the Response to Sintilimab plus Bevacizumab Biosimilar in Advanced Hepatocellular Carcinoma Patients
por: Zhang, Wen, et al.
Publicado: (2022)

Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy
por: Liu, Xia, et al.
Publicado: (2022)

Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
por: Qu, Ning, et al.
Publicado: (2013)

TOX correlates with prognosis, immune infiltration, and T cells exhaustion in lung adenocarcinoma
por: Guo, Longbin, et al.
Publicado: (2020)

Serum concentrations of IL-17A, IL-17B, IL-17E and IL-17F in patients with systemic sclerosis
por: Robak, Ewa, et al.
Publicado: (2019)

Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection
por: Rao, Deepak A., et al.
Publicado: (2008)

Diesel Exhaust Particles Upregulate Interleukins IL-6 and IL-8 in Nasal Fibroblasts
por: Kim, Jin Ah, et al.
Publicado: (2016)

A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy
por: Hsu, Eric J., et al.
Publicado: (2021)

IL-17A weakens the antitumor immuity by inhibiting apoptosis of MDSCs in Lewis lung carcinoma bearing mice
por: Wang, Juan, et al.
Publicado: (2016)

Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
por: Gordon-Alonso, Monica, et al.
Publicado: (2014)

Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma
por: Wu, Shi-yi, et al.
Publicado: (2021)

BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells
por: Seo, Hyungseok, et al.
Publicado: (2021)

The Accumulation and Prognosis Value of Tumor Infiltrating IL-17 Producing Cells in Esophageal Squamous Cell Carcinoma
por: Lv, Lin, et al.
Publicado: (2011)

Blockade of IL-23 ameliorates allergic lung inflammation via decreasing the infiltration of Tc17 cells
por: Cheng, Sheng, et al.
Publicado: (2016)

IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling
por: Goepfert, Arnaud, et al.
Publicado: (2022)

Type 17 immunity promotes the exhaustion of CD8(+) T cells in cancer
por: Kim, Byung-Seok, et al.
Publicado: (2021)

New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function
por: Saviano, Anella, et al.
Publicado: (2023)

IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis
por: Dhaouadi, Tarak, et al.
Publicado: (2018)

Correction: IL-17A weakens the antitumor immunity by inhibiting apoptosis of MDSCs in Lewis lung carcinoma bearing mice
por: Wang, Juan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gnt0bqdtsvjdg8c7vmignv83hr