Cargando…

Disease in the Pld4(thss/thss) Model of Murine Lupus Requires TLR9

Phospholipase D4 (PLD4) is an endolysosomal exonuclease of ssRNA and ssDNA, rather than a phospholipase as its name suggests. Human polymorphisms in the PLD4 gene have been linked by genome-wide association studies to systemic sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. Howeve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gavin, Amanda L., Blane, Tanya R., Thinnes, Therese C., Gerlt, Emma, Marshak-Rothstein, Ann, Huang, Deli, Nemazee, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2023
Materias:	Innate Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441812/ https://www.ncbi.nlm.nih.gov/pubmed/37555846 http://dx.doi.org/10.4049/immunohorizons.2300058

Ejemplares similares

Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
por: Gavin, Amanda L., et al.
Publicado: (2021)

Deoxyguanosine is a TLR7 agonist
por: Davenne, Tamara, et al.
Publicado: (2019)

TLR2-independent induction and regulation of chronic intestinal inflammation
por: Boulard, Olivier, et al.
Publicado: (2010)

TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN
por: Temizoz, Burcu, et al.
Publicado: (2015)

Human β‐defensin 3 increases the TLR9‐dependent response to bacterial DNA
por: McGlasson, Sarah L., et al.
Publicado: (2017)

TLR signaling in human antigen‐presenting cells regulates MR1‐dependent activation of MAIT cells
por: Ussher, James E., et al.
Publicado: (2016)

Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways
por: Dennehy, Kevin M, et al.
Publicado: (2009)

IL‐18‐induced expression of high‐affinity IL‐2R on murine NK cells is essential for NK‐cell IFN‐γ production during murine Plasmodium yoelii infection
por: Stegmann, Kerstin A., et al.
Publicado: (2015)

α‐Galactosylceramide‐activated murine NK1.1(+) invariant‐NKT cells in the myometrium induce miscarriages in mice
por: Ichikawa, Tomoko, et al.
Publicado: (2016)

Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity
por: Giles, James A, et al.
Publicado: (2015)

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors
por: Dennehy, Kevin M, et al.
Publicado: (2008)

Rapid CD4(+) T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9
por: Atif, Shaikh M, et al.
Publicado: (2015)

Depletion of CD11c(+) cells in the CD11c.DTR model drives expansion of unique CD64(+) Ly6C(+) monocytes that are poised to release TNF-α
por: Sivakumaran, Shivajanani, et al.
Publicado: (2016)

CD161(++)CD8(+) T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner
por: Ussher, James E, et al.
Publicado: (2014)

The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes
por: Hipp, Madeleine M., et al.
Publicado: (2015)

Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model
por: Youn, Ju Ho, et al.
Publicado: (2011)

A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection
por: Barr, Daniel P, et al.
Publicado: (2007)

Defensin-related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4(+) T cells independently of CCR6
por: Taylor, Karen, et al.
Publicado: (2009)

The effect of pregnancy on the uterine NK cell KIR repertoire
por: Male, Victoria, et al.
Publicado: (2011)

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance
por: Baruah, Paramita, et al.
Publicado: (2010)

Characterisation of the expression and function of the GM-CSF receptor α-chain in mice
por: Rosas, Marcela, et al.
Publicado: (2007)

Internalization of Dectin-1 terminates induction of inflammatory responses
por: Hernanz-Falcón, Patricia, et al.
Publicado: (2009)

IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation
por: Hardman, Clare S, et al.
Publicado: (2013)

NKp46 regulates allergic responses
por: Ghadially, Hormas, et al.
Publicado: (2013)

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages
por: Luheshi, Nadia M, et al.
Publicado: (2012)

KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells
por: Sim, Malcolm J. W., et al.
Publicado: (2015)

NET formation can occur independently of RIPK3 and MLKL signaling
por: Amini, Poorya, et al.
Publicado: (2015)

Pattern recognition receptor mediated downregulation of microRNA‐650 fine‐tunes MxA expression in dendritic cells infected with influenza A virus
por: Pichulik, Tica, et al.
Publicado: (2015)

A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)
por: Negm, Ola H, et al.
Publicado: (2014)

Mouse superkiller‐2‐like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses
por: Goubau, Delphine, et al.
Publicado: (2015)

TSLP production by dendritic cells is modulated by IL‐1β and components of the endoplasmic reticulum stress response
por: Elder, Matthew J., et al.
Publicado: (2015)

Peptide selectivity discriminates NK cells from KIR2DL2‐ and KIR2DL3‐positive individuals
por: Cassidy, Sorcha, et al.
Publicado: (2014)

IL‐33 delivery induces serous cavity macrophage proliferation independent of interleukin‐4 receptor alpha
por: Jackson‐Jones, Lucy H., et al.
Publicado: (2016)

Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling
por: Hertzog, Jonny, et al.
Publicado: (2018)

Human milk oligosaccharides promote immune tolerance via direct interactions with human dendritic cells
por: Xiao, Ling, et al.
Publicado: (2019)

Fc gamma receptor IIa suppresses type I and III interferon production by human myeloid immune cells
por: Newling, Melissa, et al.
Publicado: (2018)

Properdin and factor H production by human dendritic cells modulates their T‐cell stimulatory capacity and is regulated by IFN‐γ
por: Dixon, Karen O., et al.
Publicado: (2017)

A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome
por: Raijmakers, Ruud P.H., et al.
Publicado: (2019)

Recognition of S100 proteins by Signal Inhibitory Receptor on Leukocytes‐1 negatively regulates human neutrophils
por: Rumpret, Matevž, et al.
Publicado: (2021)

Identification of human cytotoxic ILC3s
por: Krabbendam, Lisette, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h1glr1i1njelcovb51gvh0nbqd