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Unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance

Stability is a fundamental ecological property of the gut microbiota and is associated with host health. Numerous studies have shown that unbalanced dietary components disturb the gut microbial composition and thereby contribute to the onset and progression of disease. However, the impact of unbalan...

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Autores principales: Sun, Penghao, Wang, Mengli, Zheng, Wei, Li, Shuzhen, Zhu, Xiaoyan, Chai, Xuejun, Zhao, Shanting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441997/
https://www.ncbi.nlm.nih.gov/pubmed/37676325
http://dx.doi.org/10.1007/s44154-023-00098-x
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author Sun, Penghao
Wang, Mengli
Zheng, Wei
Li, Shuzhen
Zhu, Xiaoyan
Chai, Xuejun
Zhao, Shanting
author_facet Sun, Penghao
Wang, Mengli
Zheng, Wei
Li, Shuzhen
Zhu, Xiaoyan
Chai, Xuejun
Zhao, Shanting
author_sort Sun, Penghao
collection PubMed
description Stability is a fundamental ecological property of the gut microbiota and is associated with host health. Numerous studies have shown that unbalanced dietary components disturb the gut microbial composition and thereby contribute to the onset and progression of disease. However, the impact of unbalanced diets on the stability of the gut microbiota is poorly understood. In the present study, four-week-old mice were fed a plant-based diet high in refined carbohydrates or a high-fat diet for four weeks to simulate a persistent unbalanced diet. We found that persistent unbalanced diets significantly reduced the gut bacterial richness and increased the complexity of bacterial co-occurrence networks. Furthermore, the gut bacterial response to unbalanced diets was phylogenetically conserved, which reduced network modularity and enhanced the proportion of positive associations between community taxon, thereby amplifying the co-oscillation of perturbations among community species to destabilize gut microbial communities. The disturbance test revealed that the gut microbiota of mice fed with unbalanced diets was less resistant to antibiotic perturbation and pathogenic bacteria invasion. This study may fill a gap in the mechanistic understanding of the gut microbiota stability in response to diet and provide new insights into the gut microbial ecology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s44154-023-00098-x.
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spelling pubmed-104419972023-08-28 Unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance Sun, Penghao Wang, Mengli Zheng, Wei Li, Shuzhen Zhu, Xiaoyan Chai, Xuejun Zhao, Shanting Stress Biol Original Paper Stability is a fundamental ecological property of the gut microbiota and is associated with host health. Numerous studies have shown that unbalanced dietary components disturb the gut microbial composition and thereby contribute to the onset and progression of disease. However, the impact of unbalanced diets on the stability of the gut microbiota is poorly understood. In the present study, four-week-old mice were fed a plant-based diet high in refined carbohydrates or a high-fat diet for four weeks to simulate a persistent unbalanced diet. We found that persistent unbalanced diets significantly reduced the gut bacterial richness and increased the complexity of bacterial co-occurrence networks. Furthermore, the gut bacterial response to unbalanced diets was phylogenetically conserved, which reduced network modularity and enhanced the proportion of positive associations between community taxon, thereby amplifying the co-oscillation of perturbations among community species to destabilize gut microbial communities. The disturbance test revealed that the gut microbiota of mice fed with unbalanced diets was less resistant to antibiotic perturbation and pathogenic bacteria invasion. This study may fill a gap in the mechanistic understanding of the gut microbiota stability in response to diet and provide new insights into the gut microbial ecology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s44154-023-00098-x. Springer Nature Singapore 2023-06-27 /pmc/articles/PMC10441997/ /pubmed/37676325 http://dx.doi.org/10.1007/s44154-023-00098-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Sun, Penghao
Wang, Mengli
Zheng, Wei
Li, Shuzhen
Zhu, Xiaoyan
Chai, Xuejun
Zhao, Shanting
Unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance
title Unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance
title_full Unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance
title_fullStr Unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance
title_full_unstemmed Unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance
title_short Unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance
title_sort unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441997/
https://www.ncbi.nlm.nih.gov/pubmed/37676325
http://dx.doi.org/10.1007/s44154-023-00098-x
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