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Pathway to global elimination of hepatitis B: HBV cure is just the first step

Hepatitis B (HBV) is a major cause of global morbidity and mortality, and the leading cause of liver cancer worldwide. Significant advances have recently been made toward the development of a finite HBV treatment that achieves permanent loss of HBsAg and HBV DNA (so-called “HBV cure”), which could p...

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Autores principales: Howell, Jessica, Seaman, Chris, Wallace, Jack, Xiao, Yinzong, Scott, Nick, Davies, Jane, de Santis, Teresa, Adda, Danjuma, El-Sayed, Manal, Feld, Jordan J., Gane, Edward, Lacombe, Karine, Lesi, Olufunmilayo, Mohamed, Rosmawati, Silva, Marcelo, Tu, Thomas, Revill, Peter, Hellard, Margaret E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442143/
https://www.ncbi.nlm.nih.gov/pubmed/37125643
http://dx.doi.org/10.1097/HEP.0000000000000430
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author Howell, Jessica
Seaman, Chris
Wallace, Jack
Xiao, Yinzong
Scott, Nick
Davies, Jane
de Santis, Teresa
Adda, Danjuma
El-Sayed, Manal
Feld, Jordan J.
Gane, Edward
Lacombe, Karine
Lesi, Olufunmilayo
Mohamed, Rosmawati
Silva, Marcelo
Tu, Thomas
Revill, Peter
Hellard, Margaret E.
author_facet Howell, Jessica
Seaman, Chris
Wallace, Jack
Xiao, Yinzong
Scott, Nick
Davies, Jane
de Santis, Teresa
Adda, Danjuma
El-Sayed, Manal
Feld, Jordan J.
Gane, Edward
Lacombe, Karine
Lesi, Olufunmilayo
Mohamed, Rosmawati
Silva, Marcelo
Tu, Thomas
Revill, Peter
Hellard, Margaret E.
author_sort Howell, Jessica
collection PubMed
description Hepatitis B (HBV) is a major cause of global morbidity and mortality, and the leading cause of liver cancer worldwide. Significant advances have recently been made toward the development of a finite HBV treatment that achieves permanent loss of HBsAg and HBV DNA (so-called “HBV cure”), which could provide the means to eliminate HBV as a public health threat. However, the HBV cure is just one step toward achieving WHO HBV elimination targets by 2030, and much work must be done now to prepare for the successful implementation of the HBV cure. In this review, we describe the required steps to rapidly scale-up future HBV cure equitably. We present key actions required for successful HBV cure implementation, integrated within the World Health Organization (WHO) Global Health Sector Strategy (GHSS) 2022–2030 framework. Finally, we highlight what can be done now to progress toward the 2030 HBV elimination targets using available tools to ensure that we are preparing, but not waiting, for the cure.
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spelling pubmed-104421432023-08-22 Pathway to global elimination of hepatitis B: HBV cure is just the first step Howell, Jessica Seaman, Chris Wallace, Jack Xiao, Yinzong Scott, Nick Davies, Jane de Santis, Teresa Adda, Danjuma El-Sayed, Manal Feld, Jordan J. Gane, Edward Lacombe, Karine Lesi, Olufunmilayo Mohamed, Rosmawati Silva, Marcelo Tu, Thomas Revill, Peter Hellard, Margaret E. Hepatology Reviews Hepatitis B (HBV) is a major cause of global morbidity and mortality, and the leading cause of liver cancer worldwide. Significant advances have recently been made toward the development of a finite HBV treatment that achieves permanent loss of HBsAg and HBV DNA (so-called “HBV cure”), which could provide the means to eliminate HBV as a public health threat. However, the HBV cure is just one step toward achieving WHO HBV elimination targets by 2030, and much work must be done now to prepare for the successful implementation of the HBV cure. In this review, we describe the required steps to rapidly scale-up future HBV cure equitably. We present key actions required for successful HBV cure implementation, integrated within the World Health Organization (WHO) Global Health Sector Strategy (GHSS) 2022–2030 framework. Finally, we highlight what can be done now to progress toward the 2030 HBV elimination targets using available tools to ensure that we are preparing, but not waiting, for the cure. Lippincott Williams & Wilkins 2023-09 2023-05-01 /pmc/articles/PMC10442143/ /pubmed/37125643 http://dx.doi.org/10.1097/HEP.0000000000000430 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Reviews
Howell, Jessica
Seaman, Chris
Wallace, Jack
Xiao, Yinzong
Scott, Nick
Davies, Jane
de Santis, Teresa
Adda, Danjuma
El-Sayed, Manal
Feld, Jordan J.
Gane, Edward
Lacombe, Karine
Lesi, Olufunmilayo
Mohamed, Rosmawati
Silva, Marcelo
Tu, Thomas
Revill, Peter
Hellard, Margaret E.
Pathway to global elimination of hepatitis B: HBV cure is just the first step
title Pathway to global elimination of hepatitis B: HBV cure is just the first step
title_full Pathway to global elimination of hepatitis B: HBV cure is just the first step
title_fullStr Pathway to global elimination of hepatitis B: HBV cure is just the first step
title_full_unstemmed Pathway to global elimination of hepatitis B: HBV cure is just the first step
title_short Pathway to global elimination of hepatitis B: HBV cure is just the first step
title_sort pathway to global elimination of hepatitis b: hbv cure is just the first step
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442143/
https://www.ncbi.nlm.nih.gov/pubmed/37125643
http://dx.doi.org/10.1097/HEP.0000000000000430
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