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Pathway to global elimination of hepatitis B: HBV cure is just the first step
Hepatitis B (HBV) is a major cause of global morbidity and mortality, and the leading cause of liver cancer worldwide. Significant advances have recently been made toward the development of a finite HBV treatment that achieves permanent loss of HBsAg and HBV DNA (so-called “HBV cure”), which could p...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442143/ https://www.ncbi.nlm.nih.gov/pubmed/37125643 http://dx.doi.org/10.1097/HEP.0000000000000430 |
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author | Howell, Jessica Seaman, Chris Wallace, Jack Xiao, Yinzong Scott, Nick Davies, Jane de Santis, Teresa Adda, Danjuma El-Sayed, Manal Feld, Jordan J. Gane, Edward Lacombe, Karine Lesi, Olufunmilayo Mohamed, Rosmawati Silva, Marcelo Tu, Thomas Revill, Peter Hellard, Margaret E. |
author_facet | Howell, Jessica Seaman, Chris Wallace, Jack Xiao, Yinzong Scott, Nick Davies, Jane de Santis, Teresa Adda, Danjuma El-Sayed, Manal Feld, Jordan J. Gane, Edward Lacombe, Karine Lesi, Olufunmilayo Mohamed, Rosmawati Silva, Marcelo Tu, Thomas Revill, Peter Hellard, Margaret E. |
author_sort | Howell, Jessica |
collection | PubMed |
description | Hepatitis B (HBV) is a major cause of global morbidity and mortality, and the leading cause of liver cancer worldwide. Significant advances have recently been made toward the development of a finite HBV treatment that achieves permanent loss of HBsAg and HBV DNA (so-called “HBV cure”), which could provide the means to eliminate HBV as a public health threat. However, the HBV cure is just one step toward achieving WHO HBV elimination targets by 2030, and much work must be done now to prepare for the successful implementation of the HBV cure. In this review, we describe the required steps to rapidly scale-up future HBV cure equitably. We present key actions required for successful HBV cure implementation, integrated within the World Health Organization (WHO) Global Health Sector Strategy (GHSS) 2022–2030 framework. Finally, we highlight what can be done now to progress toward the 2030 HBV elimination targets using available tools to ensure that we are preparing, but not waiting, for the cure. |
format | Online Article Text |
id | pubmed-10442143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-104421432023-08-22 Pathway to global elimination of hepatitis B: HBV cure is just the first step Howell, Jessica Seaman, Chris Wallace, Jack Xiao, Yinzong Scott, Nick Davies, Jane de Santis, Teresa Adda, Danjuma El-Sayed, Manal Feld, Jordan J. Gane, Edward Lacombe, Karine Lesi, Olufunmilayo Mohamed, Rosmawati Silva, Marcelo Tu, Thomas Revill, Peter Hellard, Margaret E. Hepatology Reviews Hepatitis B (HBV) is a major cause of global morbidity and mortality, and the leading cause of liver cancer worldwide. Significant advances have recently been made toward the development of a finite HBV treatment that achieves permanent loss of HBsAg and HBV DNA (so-called “HBV cure”), which could provide the means to eliminate HBV as a public health threat. However, the HBV cure is just one step toward achieving WHO HBV elimination targets by 2030, and much work must be done now to prepare for the successful implementation of the HBV cure. In this review, we describe the required steps to rapidly scale-up future HBV cure equitably. We present key actions required for successful HBV cure implementation, integrated within the World Health Organization (WHO) Global Health Sector Strategy (GHSS) 2022–2030 framework. Finally, we highlight what can be done now to progress toward the 2030 HBV elimination targets using available tools to ensure that we are preparing, but not waiting, for the cure. Lippincott Williams & Wilkins 2023-09 2023-05-01 /pmc/articles/PMC10442143/ /pubmed/37125643 http://dx.doi.org/10.1097/HEP.0000000000000430 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Reviews Howell, Jessica Seaman, Chris Wallace, Jack Xiao, Yinzong Scott, Nick Davies, Jane de Santis, Teresa Adda, Danjuma El-Sayed, Manal Feld, Jordan J. Gane, Edward Lacombe, Karine Lesi, Olufunmilayo Mohamed, Rosmawati Silva, Marcelo Tu, Thomas Revill, Peter Hellard, Margaret E. Pathway to global elimination of hepatitis B: HBV cure is just the first step |
title | Pathway to global elimination of hepatitis B: HBV cure is just the first step |
title_full | Pathway to global elimination of hepatitis B: HBV cure is just the first step |
title_fullStr | Pathway to global elimination of hepatitis B: HBV cure is just the first step |
title_full_unstemmed | Pathway to global elimination of hepatitis B: HBV cure is just the first step |
title_short | Pathway to global elimination of hepatitis B: HBV cure is just the first step |
title_sort | pathway to global elimination of hepatitis b: hbv cure is just the first step |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442143/ https://www.ncbi.nlm.nih.gov/pubmed/37125643 http://dx.doi.org/10.1097/HEP.0000000000000430 |
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