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Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme
RNA-guided type V CRISPR–Cas12 effectors provide adaptive immunity against mobile genetic elements (MGEs) in bacteria and archaea. Among diverse Cas12 enzymes, the recently identified Cas12m2 (CRISPR–Cas type V-M) is highly compact and has a unique RuvC active site. Although the non-canonical RuvC t...
Autores principales: | Omura, Satoshi N., Nakagawa, Ryoya, Südfeld, Christian, Villegas Warren, Ricardo, Wu, Wen Y., Hirano, Hisato, Laffeber, Charlie, Kusakizako, Tsukasa, Kise, Yoshiaki, Lebbink, Joyce H. G., Itoh, Yuzuru, van der Oost, John, Nureki, Osamu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442227/ https://www.ncbi.nlm.nih.gov/pubmed/37460897 http://dx.doi.org/10.1038/s41594-023-01042-3 |
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