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Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2–p53 pathways

The 5S ribonucleoprotein (RNP) is assembled from its three components (5S rRNA, Rpl5/uL18 and Rpl11/uL5) before being incorporated into the pre-60S subunit. However, when ribosome synthesis is disturbed, a free 5S RNP can enter the MDM2–p53 pathway to regulate cell cycle and apoptotic signaling. Her...

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Detalles Bibliográficos
Autores principales:	Castillo Duque de Estrada, Nestor Miguel, Thoms, Matthias, Flemming, Dirk, Hammaren, Henrik M., Buschauer, Robert, Ameismeier, Michael, Baßler, Jochen, Beck, Martin, Beckmann, Roland, Hurt, Ed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442235/ https://www.ncbi.nlm.nih.gov/pubmed/37291423 http://dx.doi.org/10.1038/s41594-023-01006-7

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