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Previous traumatic brain injury is associated with an increased odds for gestational diabetes: a nationwide register-based cohort study in finland

AIMS: Despite recent findings that traumatic brain injury (TBI) is a possible risk factor for type 2 diabetes (DM2) and that a strong association exists between gestational diabetes (GDM) and the risk for the development of DM2, no previous studies have investigated the effects of TBI on the risk fo...

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Autores principales: Vaajala, Matias, Kuitunen, Ilari, Liukkonen, Rasmus, Ponkilainen, Ville, Kekki, Maiju, Mattila, Ville M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442252/
https://www.ncbi.nlm.nih.gov/pubmed/37380726
http://dx.doi.org/10.1007/s00592-023-02129-5
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author Vaajala, Matias
Kuitunen, Ilari
Liukkonen, Rasmus
Ponkilainen, Ville
Kekki, Maiju
Mattila, Ville M.
author_facet Vaajala, Matias
Kuitunen, Ilari
Liukkonen, Rasmus
Ponkilainen, Ville
Kekki, Maiju
Mattila, Ville M.
author_sort Vaajala, Matias
collection PubMed
description AIMS: Despite recent findings that traumatic brain injury (TBI) is a possible risk factor for type 2 diabetes (DM2) and that a strong association exists between gestational diabetes (GDM) and the risk for the development of DM2, no previous studies have investigated the effects of TBI on the risk for the development of GDM. Therefore, this study aims to determine the possible association between a previous traumatic brain injury and later gestational diabetes. METHODS: In this retrospective register-based cohort study, data from the National Medical Birth Register were combined with data from the Care Register for Health Care. Women who had sustained a TBI before pregnancy were included in the patient group. Women who had sustained previous fractures of the upper extremity, pelvis, or lower extremity were included in the control group. A logistic regression model was used to assess the risk for the development of GDM during pregnancy. Adjusted odds ratios (aOR) with 95% confidence intervals between the groups were compared. The model was adjusted by prepregnancy body mass index (BMI) and maternal age during pregnancy, the use of in vitro fertilization (IVF), maternal smoking status, and multiple pregnancies. The risk for the development of GDM during different periods following the injury (0–3 years, 3–6 years, 6–9 years, and 9+ years) was calculated. RESULTS: In total, a 75 g 2-h oral glucose tolerance test (OGTT) was performed on 6802 pregnancies of women who had sustained a TBI and on 11 717 pregnancies of women who sustained fractures of the upper extremity, pelvis, or lower extremity. Of these, 1889 (27.8%) pregnancies were diagnosed with GDM in the patient group and 3117 (26.6%) in the control group. The total odds for GDM were higher after TBI compared to the other traumas (aOR 1.14, CI 1.06–1.22). The odds were highest at 9 + years after the injury (aOR 1.22, CI 1.07–1.39). CONCLUSION: The total odds for the development of GDM after TBI were higher when compared to the control group. Based on our findings, more research on this topic is warranted. Moreover, a history of TBI should be considered a possible risk factor for the development of GDM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00592-023-02129-5.
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spelling pubmed-104422522023-08-23 Previous traumatic brain injury is associated with an increased odds for gestational diabetes: a nationwide register-based cohort study in finland Vaajala, Matias Kuitunen, Ilari Liukkonen, Rasmus Ponkilainen, Ville Kekki, Maiju Mattila, Ville M. Acta Diabetol Original Article AIMS: Despite recent findings that traumatic brain injury (TBI) is a possible risk factor for type 2 diabetes (DM2) and that a strong association exists between gestational diabetes (GDM) and the risk for the development of DM2, no previous studies have investigated the effects of TBI on the risk for the development of GDM. Therefore, this study aims to determine the possible association between a previous traumatic brain injury and later gestational diabetes. METHODS: In this retrospective register-based cohort study, data from the National Medical Birth Register were combined with data from the Care Register for Health Care. Women who had sustained a TBI before pregnancy were included in the patient group. Women who had sustained previous fractures of the upper extremity, pelvis, or lower extremity were included in the control group. A logistic regression model was used to assess the risk for the development of GDM during pregnancy. Adjusted odds ratios (aOR) with 95% confidence intervals between the groups were compared. The model was adjusted by prepregnancy body mass index (BMI) and maternal age during pregnancy, the use of in vitro fertilization (IVF), maternal smoking status, and multiple pregnancies. The risk for the development of GDM during different periods following the injury (0–3 years, 3–6 years, 6–9 years, and 9+ years) was calculated. RESULTS: In total, a 75 g 2-h oral glucose tolerance test (OGTT) was performed on 6802 pregnancies of women who had sustained a TBI and on 11 717 pregnancies of women who sustained fractures of the upper extremity, pelvis, or lower extremity. Of these, 1889 (27.8%) pregnancies were diagnosed with GDM in the patient group and 3117 (26.6%) in the control group. The total odds for GDM were higher after TBI compared to the other traumas (aOR 1.14, CI 1.06–1.22). The odds were highest at 9 + years after the injury (aOR 1.22, CI 1.07–1.39). CONCLUSION: The total odds for the development of GDM after TBI were higher when compared to the control group. Based on our findings, more research on this topic is warranted. Moreover, a history of TBI should be considered a possible risk factor for the development of GDM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00592-023-02129-5. Springer Milan 2023-06-28 2023 /pmc/articles/PMC10442252/ /pubmed/37380726 http://dx.doi.org/10.1007/s00592-023-02129-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Vaajala, Matias
Kuitunen, Ilari
Liukkonen, Rasmus
Ponkilainen, Ville
Kekki, Maiju
Mattila, Ville M.
Previous traumatic brain injury is associated with an increased odds for gestational diabetes: a nationwide register-based cohort study in finland
title Previous traumatic brain injury is associated with an increased odds for gestational diabetes: a nationwide register-based cohort study in finland
title_full Previous traumatic brain injury is associated with an increased odds for gestational diabetes: a nationwide register-based cohort study in finland
title_fullStr Previous traumatic brain injury is associated with an increased odds for gestational diabetes: a nationwide register-based cohort study in finland
title_full_unstemmed Previous traumatic brain injury is associated with an increased odds for gestational diabetes: a nationwide register-based cohort study in finland
title_short Previous traumatic brain injury is associated with an increased odds for gestational diabetes: a nationwide register-based cohort study in finland
title_sort previous traumatic brain injury is associated with an increased odds for gestational diabetes: a nationwide register-based cohort study in finland
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442252/
https://www.ncbi.nlm.nih.gov/pubmed/37380726
http://dx.doi.org/10.1007/s00592-023-02129-5
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