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Source identification via contact tracing in the presence of asymptomatic patients

Inferring the source of a diffusion in a large network of agents is a difficult but feasible task, if a few agents act as sensors revealing the time at which they got hit by the diffusion. One of the main limitations of current source identification algorithms is that they assume full knowledge of t...

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Autores principales: Ódor, Gergely, Vuckovic, Jana, Ndoye, Miguel-Angel Sanchez, Thiran, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442312/
https://www.ncbi.nlm.nih.gov/pubmed/37614376
http://dx.doi.org/10.1007/s41109-023-00566-3
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author Ódor, Gergely
Vuckovic, Jana
Ndoye, Miguel-Angel Sanchez
Thiran, Patrick
author_facet Ódor, Gergely
Vuckovic, Jana
Ndoye, Miguel-Angel Sanchez
Thiran, Patrick
author_sort Ódor, Gergely
collection PubMed
description Inferring the source of a diffusion in a large network of agents is a difficult but feasible task, if a few agents act as sensors revealing the time at which they got hit by the diffusion. One of the main limitations of current source identification algorithms is that they assume full knowledge of the contact network, which is rarely the case, especially for epidemics, where the source is called patient zero. Inspired by recent implementations of contact tracing algorithms, we propose a new framework, which we call Source Identification via Contact Tracing Framework (SICTF). In the SICTF, the source identification task starts at the time of the first hospitalization, and initially we have no knowledge about the contact network other than the identity of the first hospitalized agent. We may then explore the network by contact queries, and obtain symptom onset times by test queries in an adaptive way, i.e., both contact and test queries can depend on the outcome of previous queries. We also assume that some of the agents may be asymptomatic, and therefore cannot reveal their symptom onset time. Our goal is to find patient zero with as few contact and test queries as possible. We implement two local search algorithms for the SICTF: the LS algorithm, which has recently been proposed by Waniek et al. in a similar framework, is more data-efficient, but can fail to find the true source if many asymptomatic agents are present, whereas the LS+ algorithm is more robust to asymptomatic agents. By simulations we show that both LS and LS+ outperform previously proposed adaptive and non-adaptive source identification algorithms adapted to the SICTF, even though these baseline algorithms have full access to the contact network. Extending the theory of random exponential trees, we analytically approximate the source identification probability of the LS/ LS+ algorithms, and we show that our analytic results match the simulations. Finally, we benchmark our algorithms on the Data-driven COVID-19 Simulator (DCS) developed by Lorch et al., which is the first time source identification algorithms are tested on such a complex dataset.
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spelling pubmed-104423122023-08-23 Source identification via contact tracing in the presence of asymptomatic patients Ódor, Gergely Vuckovic, Jana Ndoye, Miguel-Angel Sanchez Thiran, Patrick Appl Netw Sci Research Inferring the source of a diffusion in a large network of agents is a difficult but feasible task, if a few agents act as sensors revealing the time at which they got hit by the diffusion. One of the main limitations of current source identification algorithms is that they assume full knowledge of the contact network, which is rarely the case, especially for epidemics, where the source is called patient zero. Inspired by recent implementations of contact tracing algorithms, we propose a new framework, which we call Source Identification via Contact Tracing Framework (SICTF). In the SICTF, the source identification task starts at the time of the first hospitalization, and initially we have no knowledge about the contact network other than the identity of the first hospitalized agent. We may then explore the network by contact queries, and obtain symptom onset times by test queries in an adaptive way, i.e., both contact and test queries can depend on the outcome of previous queries. We also assume that some of the agents may be asymptomatic, and therefore cannot reveal their symptom onset time. Our goal is to find patient zero with as few contact and test queries as possible. We implement two local search algorithms for the SICTF: the LS algorithm, which has recently been proposed by Waniek et al. in a similar framework, is more data-efficient, but can fail to find the true source if many asymptomatic agents are present, whereas the LS+ algorithm is more robust to asymptomatic agents. By simulations we show that both LS and LS+ outperform previously proposed adaptive and non-adaptive source identification algorithms adapted to the SICTF, even though these baseline algorithms have full access to the contact network. Extending the theory of random exponential trees, we analytically approximate the source identification probability of the LS/ LS+ algorithms, and we show that our analytic results match the simulations. Finally, we benchmark our algorithms on the Data-driven COVID-19 Simulator (DCS) developed by Lorch et al., which is the first time source identification algorithms are tested on such a complex dataset. Springer International Publishing 2023-08-21 2023 /pmc/articles/PMC10442312/ /pubmed/37614376 http://dx.doi.org/10.1007/s41109-023-00566-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Ódor, Gergely
Vuckovic, Jana
Ndoye, Miguel-Angel Sanchez
Thiran, Patrick
Source identification via contact tracing in the presence of asymptomatic patients
title Source identification via contact tracing in the presence of asymptomatic patients
title_full Source identification via contact tracing in the presence of asymptomatic patients
title_fullStr Source identification via contact tracing in the presence of asymptomatic patients
title_full_unstemmed Source identification via contact tracing in the presence of asymptomatic patients
title_short Source identification via contact tracing in the presence of asymptomatic patients
title_sort source identification via contact tracing in the presence of asymptomatic patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442312/
https://www.ncbi.nlm.nih.gov/pubmed/37614376
http://dx.doi.org/10.1007/s41109-023-00566-3
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