The TIGIT(+) T regulatory cells subset associates with nosocomial infection and fatal outcome in COVID-19 patients under mechanical ventilation

The TIGIT(+)FOXP3(+)Treg subset (TIGIT(+)Tregs) exerts robust suppressive activity on cellular immunity and predisposes septic individuals to opportunistic infection. We hypothesized that TIGIT(+)Tregs could play an important role in intensifying the COVID-19 severity and hampering the defense again...

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Detalles Bibliográficos
Autores principales: de Lima, Mikhael Haruo Fernandes, Machado, Caio Cavalcante, Nascimento, Daniele Carvalho, Silva, Camila Meirelles S., Toller-Kawahisa, Juliana Escher, Rodrigues, Tamara Silva, Veras, Flavio Protassio, Pontelli, Marjorie Cornejo, Castro, Italo A., Zamboni, Dario Simões, Filho, José-Carlos A., Cunha, Thiago M., Arruda, Eurico, da Cunha, Larissa Dias, Oliveira, Renê D. R., Cunha, Fernando Q., Louzada-Junior, Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442317/
https://www.ncbi.nlm.nih.gov/pubmed/37604833
http://dx.doi.org/10.1038/s41598-023-39924-7

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