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Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes

Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such negative affect-induced physical s...

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Autores principales: Bogaerts, Katleen, Van Den Houte, Maaike, Jongen, Daniëlle, Ly, Huynh Giao, Coppens, Eline, Schruers, Koen, Van Diest, Ilse, Jan, Tack, Van Wambeke, Peter, Petre, Bogdan, Kragel, Philip A., Lindquist, Martin A., Wager, Tor D., Van Oudenhove, Lukas, Van den Bergh, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442365/
https://www.ncbi.nlm.nih.gov/pubmed/37604880
http://dx.doi.org/10.1038/s41398-023-02567-3
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author Bogaerts, Katleen
Van Den Houte, Maaike
Jongen, Daniëlle
Ly, Huynh Giao
Coppens, Eline
Schruers, Koen
Van Diest, Ilse
Jan, Tack
Van Wambeke, Peter
Petre, Bogdan
Kragel, Philip A.
Lindquist, Martin A.
Wager, Tor D.
Van Oudenhove, Lukas
Van den Bergh, Omer
author_facet Bogaerts, Katleen
Van Den Houte, Maaike
Jongen, Daniëlle
Ly, Huynh Giao
Coppens, Eline
Schruers, Koen
Van Diest, Ilse
Jan, Tack
Van Wambeke, Peter
Petre, Bogdan
Kragel, Philip A.
Lindquist, Martin A.
Wager, Tor D.
Van Oudenhove, Lukas
Van den Bergh, Omer
author_sort Bogaerts, Katleen
collection PubMed
description Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such negative affect-induced physical symptoms in FSS patients. Thirty patients with fibromyalgia and/or IBS and 30 healthy controls (all women) watched neutral, positive and negative affective picture blocks during functional MRI scanning and rated negative affect and physical symptoms after every block. We compared brain-wide activation during negative versus neutral picture viewing in FSS patients versus controls using robust general linear model analysis. Further, we compared neurologic pain signature (NPS), stimulus intensity-independent pain signature (SIIPS) and picture-induced negative emotion signature (PINES) responses to the negative versus neutral affect contrast and investigated whether they mediated between-group differences in affective picture-induced physical symptom reporting. More physical symptoms were reported after viewing negative compared to neutral pictures, and this effect was larger in patients than controls (p = 0.025). Accordingly, patients showed stronger activation in somatosensory regions during negative versus neutral picture viewing. NPS, but not SIIPS nor PINES, responses were higher in patients than controls during negative versus neutral pictures (p = 0.026). These differential NPS responses partially mediated between-group differences in physical symptoms. In conclusion, picture-induced negative affect elicits physical symptoms in FSS patients as a result of activation of somatosensory and nociceptive brain patterns, supporting the idea that affect-driven alterations in processing of somatic signals is a critical mechanism underlying FSS.
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spelling pubmed-104423652023-08-23 Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes Bogaerts, Katleen Van Den Houte, Maaike Jongen, Daniëlle Ly, Huynh Giao Coppens, Eline Schruers, Koen Van Diest, Ilse Jan, Tack Van Wambeke, Peter Petre, Bogdan Kragel, Philip A. Lindquist, Martin A. Wager, Tor D. Van Oudenhove, Lukas Van den Bergh, Omer Transl Psychiatry Article Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such negative affect-induced physical symptoms in FSS patients. Thirty patients with fibromyalgia and/or IBS and 30 healthy controls (all women) watched neutral, positive and negative affective picture blocks during functional MRI scanning and rated negative affect and physical symptoms after every block. We compared brain-wide activation during negative versus neutral picture viewing in FSS patients versus controls using robust general linear model analysis. Further, we compared neurologic pain signature (NPS), stimulus intensity-independent pain signature (SIIPS) and picture-induced negative emotion signature (PINES) responses to the negative versus neutral affect contrast and investigated whether they mediated between-group differences in affective picture-induced physical symptom reporting. More physical symptoms were reported after viewing negative compared to neutral pictures, and this effect was larger in patients than controls (p = 0.025). Accordingly, patients showed stronger activation in somatosensory regions during negative versus neutral picture viewing. NPS, but not SIIPS nor PINES, responses were higher in patients than controls during negative versus neutral pictures (p = 0.026). These differential NPS responses partially mediated between-group differences in physical symptoms. In conclusion, picture-induced negative affect elicits physical symptoms in FSS patients as a result of activation of somatosensory and nociceptive brain patterns, supporting the idea that affect-driven alterations in processing of somatic signals is a critical mechanism underlying FSS. Nature Publishing Group UK 2023-08-21 /pmc/articles/PMC10442365/ /pubmed/37604880 http://dx.doi.org/10.1038/s41398-023-02567-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bogaerts, Katleen
Van Den Houte, Maaike
Jongen, Daniëlle
Ly, Huynh Giao
Coppens, Eline
Schruers, Koen
Van Diest, Ilse
Jan, Tack
Van Wambeke, Peter
Petre, Bogdan
Kragel, Philip A.
Lindquist, Martin A.
Wager, Tor D.
Van Oudenhove, Lukas
Van den Bergh, Omer
Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes
title Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes
title_full Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes
title_fullStr Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes
title_full_unstemmed Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes
title_short Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes
title_sort brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442365/
https://www.ncbi.nlm.nih.gov/pubmed/37604880
http://dx.doi.org/10.1038/s41398-023-02567-3
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