Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen

Specificity remains a major challenge to current therapeutic strategies for cancer. Mutation associated neoantigens (MANAs) are products of genetic alterations, making them highly specific therapeutic targets. MANAs are HLA-presented (pHLA) peptides derived from intracellular mutant proteins that ar...

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Detalles Bibliográficos
Autores principales: Wright, Katharine M., DiNapoli, Sarah R., Miller, Michelle S., Aitana Azurmendi, P., Zhao, Xiaowei, Yu, Zhiheng, Chakrabarti, Mayukh, Shi, WuXian, Douglass, Jacqueline, Hwang, Michael S., Hsiue, Emily Han-Chung, Mog, Brian J., Pearlman, Alexander H., Paul, Suman, Konig, Maximilian F., Pardoll, Drew M., Bettegowda, Chetan, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin, Gabelli, Sandra B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442379/
https://www.ncbi.nlm.nih.gov/pubmed/37604828
http://dx.doi.org/10.1038/s41467-023-40821-w

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