Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized (13)C-labelled Z-OMPD

pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5-(13)C(2)]Z-OMPD as a hyperpolarized extracellular pH and perfusion sensor for MRI which allows to generate a multiparametric fingerprint of renal disease status and to detect local tumor ac...

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Detalles Bibliográficos
Autores principales: Grashei, Martin, Wodtke, Pascal, Skinner, Jason G., Sühnel, Sandra, Setzer, Nadine, Metzler, Thomas, Gulde, Sebastian, Park, Mihyun, Witt, Daniela, Mohr, Hermine, Hundshammer, Christian, Strittmatter, Nicole, Pellegata, Natalia S., Steiger, Katja, Schilling, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442412/
https://www.ncbi.nlm.nih.gov/pubmed/37604826
http://dx.doi.org/10.1038/s41467-023-40747-3

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