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Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas
Brain tumors account for 20–25% of pediatric cancers. The most frequent type of brain tumor is Glioma from grade I to grade IV according to the rate of malignancy. Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442509/ https://www.ncbi.nlm.nih.gov/pubmed/37614745 http://dx.doi.org/10.3389/fnut.2023.1222908 |
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author | Cecchi, Nicola Romanelli, Roberta Ricevuti, Flavia Amitrano, Marianna Carbone, Maria Grazia Dinardo, Michele Burgio, Ernesto |
author_facet | Cecchi, Nicola Romanelli, Roberta Ricevuti, Flavia Amitrano, Marianna Carbone, Maria Grazia Dinardo, Michele Burgio, Ernesto |
author_sort | Cecchi, Nicola |
collection | PubMed |
description | Brain tumors account for 20–25% of pediatric cancers. The most frequent type of brain tumor is Glioma from grade I to grade IV according to the rate of malignancy. Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each of the treatment strategies has several serious side effects. Therefore, to improve treatment efficacy, it is necessary to tailor therapies to patient and tumor characteristics, using appropriate molecular targets. An increasingly popular strategy is pharmaconutrition, which combines a tailored pharmacological treatment with a diet designed to synergize the effects of drugs. In this review we deal in the molecular mechanisms, the epigenetic effects and modulation of the oxidative stress pathway of ketogenic diets, that underlie its possible role, in the treatment of infantile gliomas, as a complementary approach to conventional cancer therapy. |
format | Online Article Text |
id | pubmed-10442509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104425092023-08-23 Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas Cecchi, Nicola Romanelli, Roberta Ricevuti, Flavia Amitrano, Marianna Carbone, Maria Grazia Dinardo, Michele Burgio, Ernesto Front Nutr Nutrition Brain tumors account for 20–25% of pediatric cancers. The most frequent type of brain tumor is Glioma from grade I to grade IV according to the rate of malignancy. Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each of the treatment strategies has several serious side effects. Therefore, to improve treatment efficacy, it is necessary to tailor therapies to patient and tumor characteristics, using appropriate molecular targets. An increasingly popular strategy is pharmaconutrition, which combines a tailored pharmacological treatment with a diet designed to synergize the effects of drugs. In this review we deal in the molecular mechanisms, the epigenetic effects and modulation of the oxidative stress pathway of ketogenic diets, that underlie its possible role, in the treatment of infantile gliomas, as a complementary approach to conventional cancer therapy. Frontiers Media S.A. 2023-08-08 /pmc/articles/PMC10442509/ /pubmed/37614745 http://dx.doi.org/10.3389/fnut.2023.1222908 Text en Copyright © 2023 Cecchi, Romanelli, Ricevuti, Amitrano, Carbone, Dinardo and Burgio. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Cecchi, Nicola Romanelli, Roberta Ricevuti, Flavia Amitrano, Marianna Carbone, Maria Grazia Dinardo, Michele Burgio, Ernesto Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
title | Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
title_full | Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
title_fullStr | Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
title_full_unstemmed | Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
title_short | Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
title_sort | current knowledges in pharmaconutrition: “ketogenics” in pediatric gliomas |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442509/ https://www.ncbi.nlm.nih.gov/pubmed/37614745 http://dx.doi.org/10.3389/fnut.2023.1222908 |
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